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EMBO Molecular Medicine

Cover image for Vol. 5 Issue 9

September 2013

Volume 5, Issue 9

Pages 1297–1457

  1. Closeup

    1. Top of page
    2. Closeup
    3. Bridge the Gap
    4. Research Articles
    5. Masthead
    1. You have full text access to this OnlineOpen article
  2. Bridge the Gap

    1. Top of page
    2. Closeup
    3. Bridge the Gap
    4. Research Articles
    5. Masthead
    1. You have full text access to this OnlineOpen article
      Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans (pages 1300–1310)

      Filipe Cabreiro and David Gems

      Article first published online: 1 AUG 2013 | DOI: 10.1002/emmm.201100972

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      This “bridge-the-gap” discusses the helpful and harmful relationships between microbiota and its host, and provides an interesting perspective of using worms as model organism to better understand the complexity of microbiota, aging, and metabolism.

  3. Research Articles

    1. Top of page
    2. Closeup
    3. Bridge the Gap
    4. Research Articles
    5. Masthead
    1. You have full text access to this OnlineOpen article
      STIM1 and STIM2-mediated Ca2+ influx regulates antitumour immunity by CD8+ T cells (pages 1311–1321)

      Carl Weidinger, Patrick J. Shaw and Stefan Feske

      Article first published online: 6 AUG 2013 | DOI: 10.1002/emmm.201302989

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      Cytotoxic lymphocytes are critical for antitumor immunity. Here, store operated calcium entry (SOCE) mediated by STIM1 and -2 is shown essential to CD8+ T cells antitumor immune responses, arguing against the use of drugs inhibiting SOCE.

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      A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth (pages 1322–1334)

      Yuqing Zhang, Jingxuan Yang, Xiaobo Cui, Yong Chen, Vivian F. Zhu, John P. Hagan, Huamin Wang, Xianjun Yu, Sally E. Hodges, Jing Fang, Paul J. Chiao, Craig D. Logsdon, William E. Fisher, F. Charles Brunicardi, Changyi Chen, Qizhi Yao, Martin E. Fernandez-Zapico and Min Li

      Article first published online: 16 JUL 2013 | DOI: 10.1002/emmm.201302507

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      Zinc importer ZIP4 enhancement of cell proliferation, invasion, and tumor growth in pancreatic cancer occurs through the induction of miR-373 expression by the zinc-dependent transcription factor CREB.

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      Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells (pages 1335–1350)

      Albana Gattelli, Ivan Nalvarte, Anne Boulay, Tim C. Roloff, Martin Schreiber, Neil Carragher, Kenneth K. Macleod, Michaela Schlederer, Susanne Lienhard, Lukas Kenner, Maria I. Torres-Arzayus and Nancy E. Hynes

      Article first published online: 19 JUL 2013 | DOI: 10.1002/emmm.201302625

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      Receptor tyrosine kinases (RTK) are validated targets for cancer therapy, but only subsets of patients are eligible for this treatment. Ret inhibition blocks a novel Ret-IL6 feed-forward loop, tumor growth and metastasis of ER+ breast cancers.

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      Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia (pages 1351–1366)

      Jung Eun Park, Hiu Fung Yuen, Jian Biao Zhou, Abdul Qader O. Al-aidaroos, Ke Guo, Peter J. Valk, Shu Dong Zhang, Wee Joo Chng, Cheng William Hong, Ken Mills and Qi Zeng

      Article first published online: 8 AUG 2013 | DOI: 10.1002/emmm.201202183

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      PRL-3, a downstream target of FLT3-ITD, controls leukemia development and higher PRL-3 expression was significantly associated with shorter survival in AML patients. When targeted with an antibody, tumor burden in a leukemia mouse model is reduced.

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      Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence (pages 1367–1382)

      Veronika Hampl, Claudia Martin, Achim Aigner, Sabrina Hoebel, Stephan Singer, Natalie Frank, Antonio Sarikas, Oliver Ebert, Ron Prywes, Thomas Gudermann and Susanne Muehlich

      Article first published online: 29 JUL 2013 | DOI: 10.1002/emmm.201202406

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      MKL1 and 2 are promising novel therapeutic targets in DLC1-deficient hepatocellular carcinoma. As tumor suppressors such as DLC1 are generally not amenable to direct therapeutic targeting, targeting of MKL1∕2 might bear enormous potential.

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      Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation (pages 1383–1401)

      Kouji Izumi, Lei-Ya Fang, Atsushi Mizokami, Mikio Namiki, Lei Li, Wen-Jye Lin and Chawnshang Chang

      Article first published online: 27 AUG 2013 | DOI: 10.1002/emmm.201202367

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      Ablation of androgen receptor in myeloid or prostate cells promotes metastatic progression of prostate cancer cells through induction of CCL2 via STAT3 activation by down-regulation of the STAT3 inhibitor PIAS3.

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      MicroRNA expression profile and functional analysis reveal that miR-382 is a critical novel gene of alcohol addiction (pages 1402–1414)

      Jingyuan Li, Jing Li, Xiaojun Liu, Shanshan Qin, Yanzhong Guan, Yuwei Liu, Yunhui Cheng, Xiuwen Chen, Wen Li, Shenming Wang, Ming Xiong, Eldo V. Kuzhikandathil, Jiang-Hong Ye and Chunxiang Zhang

      Article first published online: 22 JUL 2013 | DOI: 10.1002/emmm.201201900

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      The underlying molecular causes of alcohol addiction remain unclear. Many miRNAs are found modulated in the nucleus accumbens of rats chronically treated with alcohol. Specifically, miR-382 is shown to regulate alcohol intake via DRD1 and DeltaFosB.

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      VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy (pages 1415–1430)

      Minah Kim, Hyeung Ju Park, Jae Won Seol, Jeon Yeob Jang, Young-Suk Cho, Kyu Rae Kim, Youngsok Choi, John P. Lydon, Francesco J. DeMayo, Masabumi Shibuya, Napoleone Ferrara, Hoon-Ki Sung, Andras Nagy, Kari Alitalo and Gou Young Koh

      Article first published online: 2 AUG 2013 | DOI: 10.1002/emmm.201302618

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      VEGFR2 and Tie2 differentially regulate decidual angiogenesis and vascular remodelling in rapidly growing and regressing uteri, questioning the use of treatments affecting these pathways during pregnancy and postpartum.

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      Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation (pages 1431–1442)

      Yongbo Wang, Andreas Gogol-Döring, Hao Hu, Sebastian Fröhler, Yunxia Ma, Marvin Jens, Jonas Maaskola, Yasuhiro Murakawa, Claudia Quedenau, Markus Landthaler, Vera Kalscheuer, Dagmar Wieczorek, Yang Wang, Yuhui Hu and Wei Chen

      Article first published online: 22 AUG 2013 | DOI: 10.1002/emmm.201302663

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      This study establishes RBM10 as an important regulator of alternative splicing and explains the splicing defects in TARP syndrome patients with in-frame RBM10 deletions.

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      Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid (pages 1443–1457)

      Cathal McCarthy, Nora T. Lieggi, Denis Barry, Declan Mooney, Monica de Gaetano, William G. James, Sarah McClelland, Mary C. Barry, Laure Escoubet-Lozach, Andrew C. Li, Christopher K Glass, Desmond J. Fitzgerald and Orina Belton

      Article first published online: 21 AUG 2013 | DOI: 10.1002/emmm.201302587

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      CLA inhibition of foam cell formation is linked to induction of PGC-1α and macrophage specific deletion of PGC-1α increases atherosclerosis in vivo. PGC-1α is expressed in patient plaques, suggesting that it is a regulatory pathway in atherosclerosis.

  4. Masthead

    1. Top of page
    2. Closeup
    3. Bridge the Gap
    4. Research Articles
    5. Masthead
    1. You have full text access to this OnlineOpen article
      Masthead (EMBO Mol. Med. 9/2013) (pages i–ii)

      Article first published online: 3 SEP 2013 | DOI: 10.1002/emmm.201370082

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