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EMBO Molecular Medicine

Cover image for Vol. 6 Issue 1

January 2014

Volume 6, Issue 1

Pages 1–154

  1. Editorial

    1. Top of page
    2. Editorial
    3. Closeup
    4. Reviews
    5. Research Articles
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      EMBO Molecular Medicine: Fast Forward (page 1)

      Stefanie Dimmeler, Céline Carret and Roberto Buccione

      Article first published online: 9 JAN 2014 | DOI: 10.1002/emmm.201303745

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      The new EMBO Press publishing platform reinforces the standing of EMBO Molecular Medicine as the journal that matches high quality and novel research with rigorous editorial and ethical standards, and cements the journal's global reach and relevance.

  2. Closeup

    1. Top of page
    2. Editorial
    3. Closeup
    4. Reviews
    5. Research Articles
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      An acute phase protein ready to go therapeutic for sepsis (pages 2–3)

      Sofie Vandevyver, Lien Dejager, Roosmarijn E Vandenbroucke and Claude Libert

      Article first published online: 9 JAN 2014 | DOI: 10.1002/emmm.201303524

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      While APP are well-known inflammation biomarkers, A2MG found in sepsis patients' sera within lipid microparticles is an essential player in the host response to sepsis and has diagnostic as well as therapeutic potentials.

  3. Reviews

    1. Top of page
    2. Editorial
    3. Closeup
    4. Reviews
    5. Research Articles
    1. You have full text access to this OnlineOpen article
      Emerging therapies for the treatment of hepatitis C (pages 4–15)

      Christian M Lange, Ira M Jacobson, Charles M Rice and Stefan Zeuzem

      Article first published online: 16 SEP 2013 | DOI: 10.1002/emmm.201303131

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      Normal and cancer breast stem cell in vivo self-renewal, chemoresistance and tumor growth is regulated by the prolyl-isomerase Pin1 by promoting Notch1 and Notch4 escape from major ubiquitin-ligase Fbxw7alphamediated proteasomal degradation.

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      mRNA 3′end processing: A tale of the tail reaches the clinic (pages 16–26)

      Ina Hollerer, Kerstin Grund, Matthias W. Hentze and Andreas E Kulozik

      Article first published online: 9 OCT 2013 | DOI: 10.1002/emmm.201303300

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      By connecting human diseases with mRNA 3' end formation and process, this comprehensive review provides a timely and useful memento to biologists and clinicians that the deregulation of gene expression can terribly affect human health.

  4. Research Articles

    1. Top of page
    2. Editorial
    3. Closeup
    4. Reviews
    5. Research Articles
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      Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis (pages 27–42)

      Jesmond Dalli, Lucy V Norling, Trinidad Montero-Melendez, Donata Federici Canova, Hazem Lashin, Anton M Pavlov, Gleb B Sukhorukov, Charles J Hinds and Mauro Perretti

      Article first published online: 16 DEC 2013 | DOI: 10.1002/emmm.201303503

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      A specific subset of microparticles enriched in Alpha-2-macroglobulin (A2MG) previously found increased in the plasma of sepsis patients, are now shown to protect septic mice from dying and improve the containment and clearance of bacteria.

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      Fas (CD95) expression in myeloid cells promotes obesity-induced muscle insulin resistance (pages 43–56)

      Stephan Wueest, Rouven Mueller, Matthias Blüher, Flurin Item, Annie S H Chin, Michael S F Wiedemann, Hitoshi Takizawa, Larisa Kovtonyuk, Alexander V Chervonsky, Eugen J Schoenle, Markus G Manz and Daniel Konrad

      Article first published online: 6 NOV 2013 | DOI: 10.1002/emmm.201302962

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      Fas expression in circulating monocytes correlates with skeletal muscle insulin resistance in obese humans and loss of Fas in myeloid cells decreases the release of TNFα and thus protects mice from obesity-induced skeletal muscle insulin resistance.

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      PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity (pages 57–65)

      Mirko Völkers, Shirin Doroudgar, Nathalie Nguyen, Mathias H Konstandin, Pearl Quijada, Shabana Din, Luis Ornelas, Donna J Thuerauf, Natalie Gude, Kilian Friedrich, Stephan Herzig, Christopher C Glembotski and Mark A Sussman

      Article first published online: 31 OCT 2013 | DOI: 10.1002/emmm.201303183

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      Over-expressing PRAS40 mice are protected against diabetic cardiomyopathy by reducing mTORC1 levels thereby preventing cellular remodeling and dysfunction. This data suggest a novel therapeutic approach against diabeticrelated diseases.

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      Sox2 promotes tamoxifen resistance in breast cancer cells (pages 66–79)

      Marco Piva, Giacomo Domenici, Oihana Iriondo, Miriam Rábano, Bruno M Simões, Valentine Comaills, Inmaculada Barredo, Jose A López-Ruiz, Ignacio Zabalza, Robert Kypta and Maria d M Vivanco

      Article first published online: 31 OCT 2013 | DOI: 10.1002/emmm.201303411

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      The development of Tam-resistance in breast cancer is shown to be driven by Sox2-dependent activation of Wnt signalling in cancer stem cells. Combining hormone therapy and Wnt secretion inhibitors might thus provide a novel strategy to treat breast cancer.

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      Src is activated by the nuclear receptor peroxisome proliferator-activated receptor β/δ in ultraviolet radiation-induced skin cancer (pages 80–98)

      Alexandra Montagner, Maria B Delgado, Corinne Tallichet-Blanc, Jeremy S K Chan, Ming K Sng, Hélène Mottaz, Gwendoline Degueurce, Yannick Lippi, Catherine Moret, Michael Baruchet, Maria Antsiferova, Sabine Werner, Daniel Hohl, Talal Al Saati, Pierre J Farmer, Nguan S Tan, Liliane Michalik and Walter Wahli

      Article first published online: 6 NOV 2013 | DOI: 10.1002/emmm.201302666

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      PPARβ/δ regulates Src gene expression and activity in response to UV. In human skin cancer PPARβ/δ expression was also positively correlated with SRC expression with interaction between PPARβ/δ, SRC and TGFβ1 at the transcriptional level.

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      Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast (pages 99–119)

      Alessandra Rustighi, Alessandro Zannini, Luca Tiberi, Roberta Sommaggio, Silvano Piazza, Giovanni Sorrentino, Simona Nuzzo, Antonella Tuscano, Vincenzo Eterno, Federica Benvenuti, Libero Santarpia, Iannis Aifantis, Antonio Rosato, Silvio Bicciato, Alberto Zambelli and Giannino Del Sal

      Article first published online: 16 DEC 2013 | DOI: 10.1002/emmm.201302909

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      Normal and cancer breast stem cell in vivo self-renewal, chemoresistance and tumor growth is regulated by the prolyl-isomerase Pin1 by promoting Notch1 and Notch4 escape from major ubiquitin-ligase Fbxw7alpha mediated proteasomal degradation.

    7. You have full text access to this OnlineOpen article
      Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia (pages 120–140)

      Ju Cao, Dongsheng Wang, Fang Xu, Yi Gong, Hong Wang, Zixin Song, Dageng Li, Hua Zhang, Dairong Li, Liping Zhang, Yun Xia, Huajian Xu, Xaiofei Lai, Shihui Lin, Xuemei Zhang, Guosheng Ren, Yubing Dai and Yibing Yin

      Article first published online: 29 OCT 2013 | DOI: 10.1002/emmm.201302890

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      Influenza infection is shown to induce pulmonary IL27 production in an IFNAR-dependent manner, by directly and indirectly suppressing IL17A production by γδ T cells, which result in increased sensitivity to secondary pneumococcal infection in vivo.

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      A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media (pages 141–154)

      Jason W Rosch, Amy R Iverson, Jessica Humann, Beth Mann, Geli Gao, Peter Vogel, Michael Mina, Kyle A Murrah, Antonia C Perez, W Edward Swords, Elaine I Tuomanen and Jonathan A McCullers

      Article first published online: 4 NOV 2013 | DOI: 10.1002/emmm.201202150

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      Pneumococcal vaccines prevent sepsis and meningitis-induced diseases but not otitis media, sinusitis, or pneumonia. A novel live genetically attenuated pneumococcal vaccine is shown protective against mucosal infections in mice and chinchilla models.

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