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EMBO Molecular Medicine

Cover image for Vol. 6 Issue 7

July 2014

Volume 6, Issue 7

Pages 851–992

  1. Review

    1. Top of page
    2. Review
    3. Research Articles
    4. Report
    1. You have full text access to this OnlineOpen article
      Development of microRNA therapeutics is coming of age (pages 851–864)

      Eva van Rooij and Sakari Kauppinen

      Version of Record online: 16 JUN 2014 | DOI: 10.15252/emmm.201100899

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      This review provides an overview of the current strategies for therapeutic modulation of miRNAs and describes selected microRNA therapies which are moving ahead for the treatment of HCV, cardiovascular diseases as well as cancer.

  2. Research Articles

    1. Top of page
    2. Review
    3. Research Articles
    4. Report
    1. You have full text access to this OnlineOpen article
      RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation (pages 865–881)

      Mònica Morales, Enrique J Arenas, Jelena Urosevic, Marc Guiu, Esther Fernández, Evarist Planet, Robert Bryn Fenwick, Sonia Fernández-Ruiz, Xavier Salvatella, David Reverter, Arkaitz Carracedo, Joan Massagué and Roger R Gomis

      Version of Record online: 27 MAY 2014 | DOI: 10.15252/emmm.201303675

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      Loss of RARRES3 facilitates breast cancer cell extravasation, lung extracellular matrix adherence, and lung colonization. Furthermore, RARRES3 levels in the primary tumor may predict risk of relapse and might help identify therapy-resistant tumors.

    2. You have full text access to this OnlineOpen article
      A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12 (pages 882–901)

      Arnaud Duquet, Alice Melotti, Sonakshi Mishra, Monica Malerba, Chandan Seth, Arwen Conod and Ariel Ruiz i Altaba

      Version of Record online: 11 JUN 2014 | DOI: 10.15252/emmm.201303799

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      Two novel metastatic suppressors TMED3 and SOX12, derived from an innovative, unbiased, in vivo, shRNA genome-wide screen, are shown to be positive modulators of WNT signaling. Their suppression causes an increase in metastasis from a primary tumor.

    3. You have full text access to this OnlineOpen article
      Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents (pages 902–917)

      Mauricio G Martin, Tariq Ahmed, Alejandra Korovaichuk, Cesar Venero, Silvia A Menchón, Isabel Salas, Sebastian Munck, Oscar Herreras, Detlef Balschun and Carlos G Dotti

      Version of Record online: 30 MAY 2014 | DOI: 10.15252/emmm.201303711

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      It is well established that cognitive deficits go hand in hand with aging. Restoring cholesterol levels in the aged hippocampus to values found in the young can rescue learning and memory in the old, linking age-dependent cholesterol decline with synaptic plasticity and neuronal function.

    4. You have full text access to this OnlineOpen article
      Affinity proteomics within rare diseases: a BIO-NMD study for blood biomarkers of muscular dystrophies (pages 918–936)

      Burcu Ayoglu, Amina Chaouch, Hanns Lochmüller, Luisa Politano, Enrico Bertini, Pietro Spitali, Monika Hiller, Eric H Niks, Francesca Gualandi, Fredrik Pontén, Kate Bushby, Annemieke Aartsma-Rus, Elena Schwartz, Yannick Le Priol, Volker Straub, Mathias Uhlén, Sebahattin Cirak, Peter A C ‘t Hoen, Francesco Muntoni, Alessandra Ferlini, Jochen M Schwenk, Peter Nilsson and Cristina Al-Khalili Szigyarto

      Version of Record online: 11 JUN 2014 | DOI: 10.15252/emmm.201303724

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      More accurate tests to improve the clinical management of Duchenne muscular dystrophy are greatly needed to improve patients' life quality. Affinity proteomics across several geographically dispersed cohorts reveals molecular biomarkers associated with disease severity and progression.

    5. You have full text access to this OnlineOpen article
      Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder (pages 937–951)

      Corinna Friedrich, Susanne Rinné, Sven Zumhagen, Aytug K Kiper, Nicole Silbernagel, Michael F Netter, Birgit Stallmeyer, Eric Schulze-Bahr and Niels Decher

      Version of Record online: 27 JUN 2014 | DOI: 10.15252/emmm.201303783

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      A novel exonic mutation in the K2P potassium channel TASK-4 is found in a patient with severe PCCD, resulting in a gain-of-function that could explain the severe progressive conduction disorder compared to isolated loss-of-function mutations in SCN5A channels.

    6. You have full text access to this OnlineOpen article
      IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms (pages 952–969)

      Jing Wang, Jes S Lindholt, Galina K Sukhova, Michael A Shi, Mingcan Xia, Han Chen, Meixiang Xiang, Aina He, Yi Wang, Na Xiong, Peter Libby, Jian-An Wang and Guo-Ping Shi

      Version of Record online: 24 JUN 2014 | DOI: 10.15252/emmm.201303811

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      This study demonstrates the pathologic role of IgE and its high affinity receptor FcεR1 in AAAs by activating MCs, macrophages but also CD4 and CD8 T cells and suggests anti-IgE antibodies as future putative therapeutics for treatment.

    7. You have full text access to this OnlineOpen article
      Epidermal p65/NF-κB signalling is essential for skin carcinogenesis (pages 970–983)

      Chun Kim and Manolis Pasparakis

      Version of Record online: 21 JUN 2014 | DOI: 10.15252/emmm.201303541

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      p65-dependent NF-κB signalling in keratinocytes promotes DMBA-/TPA-induced skin carcinogenesis by protecting them from DNA damage-induced death.

  3. Report

    1. Top of page
    2. Review
    3. Research Articles
    4. Report
    1. You have full text access to this OnlineOpen article
      The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells (pages 984–992)

      Elise Pepermans, Vincent Michel, Richard Goodyear, Crystel Bonnet, Samia Abdi, Typhaine Dupont, Souad Gherbi, Muriel Holder, Mohamed Makrelouf, Jean-Pierre Hardelin, Sandrine Marlin, Akila Zenati, Guy Richardson, Paul Avan, Amel Bahloul and Christine Petit

      Version of Record online: 17 JUN 2014 | DOI: 10.15252/emmm.201403976

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      Pcdh15-CD2 isoform is shown essential for auditory function in mature hair cells both in humans and mice but not for visual function and make the lower part of the tip-link in inner ears. This is a major advance for the development of gene therapy for deafness caused by PCDH15 defects.

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