The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy (pages 1161–1174)
Conor McCloskey, Cara Rada, Elizabeth Bailey, Samantha McCavera, Hugo A van den Berg, Jolene Atia, David A Rand, Anatoly Shmygol, Yi-Wah Chan, Siobhan Quenby, Jan J Brosens, Manu Vatish, Jie Zhang, Jerod S Denton, Michael J Taggart, Catherine Kettleborough, David Tickle, Jeff Jerman, Paul Wright, Timothy Dale, Srinivasan Kanumilli, Derek J Trezise, Steve Thornton, Pamela Brown, Roberto Catalano, Nan Lin, Sarah K England and Andrew M Blanks
Article first published online: 23 JUL 2014 | DOI: 10.15252/emmm.201403944
Only few effective treatments can manipulate uterine contractility for the prevention of dystocia, preterm labor or post-partum hemorrhage. This study reveals Kir7.1 channel as a potential target for increasing uterine contractions and identifies novel Kir7.1 inhibitors.