Green and fast procedure to obtainN-alkylbenzimidazole derivatives under microwave activation

Authors

  • V. Calvino-Casilda,

    Corresponding author
    1. Instituto de Catálisis y Petroleoquímica (C.S.I.C.), Campus UAM, Cantoblanco, E-28049-Madrid, Spain
    • Instituto de Catálisis y Petroleoquímica (C.S.I.C.), Campus UAM, Cantoblanco, E-28049-Madrid, Spain
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  • R.M. Martín-Aranda,

    1. Departamento de Química Inorgánica y Química Técnica, Universidad Nacional de Educación a Distancia (UNED), C/Senda del Rey 9, E-28040-Madrid, Spain
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  • A.J. López-Peinado

    1. Departamento de Química Inorgánica y Química Técnica, Universidad Nacional de Educación a Distancia (UNED), C/Senda del Rey 9, E-28040-Madrid, Spain
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Abstract

In this research, we report for the first time the one-pot microwave-assisted synthesis of N-butylbenzimidazole derivatives via alkylation of benzimidazole with 1-bromobutane over alkali-metal doped carbons in absence of any solvent. N-alkylbenzimidazole derivatives are produced in high yields and in very short reaction times when NaCs-Norit is used as catalyst (ca. 75% in 5 min). Thus the combination of microwaves and basic carbons in dry media leads to the simplest, most eco-efficient and fastest procedure reported so far for the preparation of benzimidazole derivatives with pharmacological properties. Under these mild reaction conditions, N-butylbenzimidazoles are obtained with total selectivity to be used in many important industrial applications. © 2010 American Institute of Chemical Engineers Environ Prog, 2011

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