The effect of collision between adjacent reinforced concrete building frames under multiple earthquakes is investigated in this paper. The four planar frames and the nine different pairs of adjacent reinforced concrete structures of the first companion paper are also examined here, under five real seismic sequences. Such a sequence of earthquakes results in a significant damage accumulation in a structure because any rehabilitation action between any two successive seismic motions cannot be practically materialised because of lack of time. Various parameters are investigated, such as the maximum horizontal displacement of top floor, ductility of columns, permanent displacements and so on. Furthermore, four different separation gaps between the building frames are considered to determine their influence on the behaviour of these frames. It is concluded that in most of the cases, the seismic sequences appear to be detrimental in comparison with the single seismic events. Copyright © 2013 John Wiley & Sons, Ltd.