We examined changes in weight-specific health-related quality of life (HRQOL) and the relation to weight loss in a Serbian population undergoing diet-induced weight loss treatment. HRQOL was assessed at intake and after 1 year using the Impact of Weight on Quality of Life-Lite (IWQOL-Lite) questionnaire. Study sample consists of 135 obese patients. After 1 year of diet therapy, patients experienced an average weight loss of ~12%, and significant improvements were noted in all IWQOL-Lite domains (Physical Function, Self-esteem, Sexual Life, Public Distress and Work). Amount of weight loss was closely linked to all domains (F = 27.49; p < 0.001), except Sexual Life (F = 2.08; p = 0.108). In patients with weight reductions of 5%–9.99%, there was a great improvement in physical function and self-esteem. In those with ≥10% weight loss, there was improvement in all dimensions of IWQOL-Lite. With the prevalence of obesity rising worldwide, including in Serbia, the positive effects of weight loss on weight-specific HRQOL are encouraging. Copyright © 2011 John Wiley & Sons, Ltd and Eating Disorders Association.