Review

Structural Magnetic Resonance Imaging in Eating Disorders: A Systematic Review of Voxel-Based Morphometry Studies

  1. Frederique Van den Eynde1,†,*,
  2. Masashi Suda1,†,
  3. Hannah Broadbent1,†,
  4. Sébastien Guillaume1,2,
  5. Magali Van den Eynde1,
  6. Howard Steiger3,
  7. Mimi Israel3,
  8. Marcelo Berlim4,
  9. Vincent Giampietro5,
  10. Andrew Simmons5,6,
  11. Janet Treasure1,
  12. Iain Campbell1,
  13. Ulrike Schmidt1

Article first published online: 3 NOV 2011

DOI: 10.1002/erv.1163

Issue

European Eating Disorders Review

European Eating Disorders Review

Volume 20, Issue 2, pages 94–105, March 2012

Additional Information

How to Cite

Van den Eynde, F., Suda, M., Broadbent, H., Guillaume, S., Van den Eynde, M., Steiger, H., Israel, M., Berlim, M., Giampietro, V., Simmons, A., Treasure, J., Campbell, I. and Schmidt, U. (2012), Structural Magnetic Resonance Imaging in Eating Disorders: A Systematic Review of Voxel-Based Morphometry Studies. Eur. Eat. Disorders Rev., 20: 94–105. doi: 10.1002/erv.1163

Author Information

  1. 1

    King's College London, Institute of Psychiatry, Department of Psychological Medicine, Section of Eating Disorders, London, UK

  2. 2

    Universite Montpellier, INSERM U1061, CHU de Montpellier, Montpellier, France

  3. 3

    Douglas University Institute, Psychiatry Department, McGill University, Eating Disorders Program, Montreal, Quebec, Canada

  4. 4

    Douglas University Institute, Psychiatry Department, McGill University, Depressive Disorders Program, Montreal, Quebec, Canada

  5. 5

    King's College London, Institute of Psychiatry, Department of Neuroimaging, London, UK

  6. 6

    NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London

  1. †

    FVDE, MS and HB have equally contributed to the manuscript.

*Frederique Van den Eynde, Department of Psychological Medicine, Section of Eating Disorders, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK. Tel: 00442078480160; Fax: 00442078480182.
E-mail: frederique.van_den_eynde@kcl.ac.uk

  • †

    FVDE, MS and HB have equally contributed to the manuscript.

Publication History

  1. Issue published online: 24 FEB 2012
  2. Article first published online: 3 NOV 2011
  3. Manuscript Accepted: 25 SEP 2011
  4. Manuscript Revised: 22 SEP 2011
  5. Manuscript Received: 15 AUG 2011

Funded by

  • Department of Health
  • National Institute for Health Research (NIHR)
  • Biomedical Research Centre for Mental Health
  • South London and Maudsley NHS Foundation Trust
  • Institute of Psychiatry, King's College London
  • National Institute for Health Research (NIHR). Grant Number: RP-PG-0606-1043
  • Programme Grants for Applied Research Scheme

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Keywords:

  • neuroimaging;
  • voxel-based morphometry;
  • anorexia nervosa;
  • bulimia nervosa;
  • systematic review

Abstract

This systematic review summarises and critically appraises the literature on structural magnetic resonance imaging in people with a current or past eating disorder. Studies using voxel-based morphometry image analysis were included. Ten studies reported on a total of 236 people with a current or past eating disorder and 257 healthy controls. Sample heterogeneity prohibited a meta-analytic approach. The findings do not unequivocally indicate grey or white matter volume abnormalities in people with an eating disorder. Nevertheless, these preliminary data suggest that, compared with healthy controls, people with anorexia nervosa have decreased grey matter in a range of brain regions and that those with bulimia nervosa have increased grey matter volumes in frontal and ventral striatal areas. Research in the recovery phase and longitudinal studies suggest that potential brain tissue abnormalities may recover with clinical improvement. Overall, as the available data are inconclusive, further efforts in this field are warranted. Copyright © 2011 John Wiley & Sons, Ltd and Eating Disorders Association.

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