Improvements in Symptoms Following Neuronavigated Repetitive Transcranial Magnetic Stimulation (rTMS) in Severe and Enduring Anorexia Nervosa: Findings from two Case Studies
Article first published online: 24 OCT 2013
Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.
European Eating Disorders Review
Special Issue: BRAIN-DIRECTED TREATMENTS IN EATING DISORDERS
Volume 21, Issue 6, pages 500–506, November 2013
How to Cite
McClelland, J., Bozhilova, N., Nestler, S., Campbell, I. C., Jacob, S., Johnson-Sabine, E. and Schmidt, U. (2013), Improvements in Symptoms Following Neuronavigated Repetitive Transcranial Magnetic Stimulation (rTMS) in Severe and Enduring Anorexia Nervosa: Findings from two Case Studies. Eur. Eat. Disorders Rev., 21: 500–506. doi: 10.1002/erv.2266
- Issue published online: 24 OCT 2013
- Article first published online: 24 OCT 2013
- anorexia nervosa (AN);
- repetitive transcranial magnetic stimulation (rTMS);
- dorsolateral prefrontal cortex (DLPFC)
Advances in the treatment of anorexia nervosa (AN) are most likely to arise from targeted, brain-directed treatments, such as repetitive transcranial magnetic stimulation (rTMS). We describe findings from two individuals with treatment-resistant AN who received 19–20 sessions of neuronavigated, high frequency rTMS, applied to the left dorsolateral prefrontal cortex.
Within-session measures assessed changes pre-rTMS, post-rTMS in subjective eating disorder (ED) experiences. Weight, ED symptoms and mood were assessed pre-treatment, post-treatment and at 1 month follow-up.
In both cases, there was improvement in ED symptomatology and mood after 19–20 sessions of neuronavigated rTMS, and these changes persisted or continued to improve at follow-up. Within sessions, Patient A demonstrated a consistent reduction in subjective ED experiences, and Patient B a reduction in some ED related experiences.
These findings suggest that rTMS has potential as an adjunct to the treatment of AN and deserves further study. Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.