• 1
    Bliss CI. 1939. The toxicity of poisons applied jointly. Ann Appl Biol 26: 585615.
  • 2
    Loureiro S, Svendsen C, Ferreira ALG, Pinheiro C, Ribeiro F, Soares AMVM. 2010. Toxicity of three binary mixtures to Daphnia magna: Comparing chemical modes of action and deviations from conceptual models. Environ Toxicol Chem 29: 17161726.
  • 3
    Altenburger R, Schmitt H, Schüürmann G. 2005. Algal toxicity of nitrobenzenes: Combined effect analysis as a pharmacological probe for similar modes of interaction. Environ Toxicol Chem 24: 324333.
  • 4
    Leblanc GA, Wang G. 2006. Chemical mixtures greater than additive effects. Environ Health Perspect 114: 517518.
  • 5
    U.S. Environmental Protection Agency. 2000. Supplementary guidance for conducting health risk assessment of chemical mixtures. EPA/630/R-00/002. Risk Assessment Forum Technical Panel. Washington, DC.
  • 6
    Van Gestel CaM, Groten JP, Jonker M. 2010. Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology. CRC, Boca Raton, FL, USA.
  • 7
    Steevens JA, Benson WH. 2000. Interactions of chlorpyrifos and methyl mercury: A mechanistic approach to assess chemical mixtures. Mar Environ Res 50: 113117.
  • 8
    Karelson M, Lobanov VS, Katritzky AR. 1996. Quantum-chemical descriptors in QSAR/QSPR studies. Chem Rev 96: 10271043.
  • 9
    Organization for Economic Cooperation and Development. 2007. Guidance document on the validation of (quantitative) structure-activity relationships models. ENV/JM/MONO (2007) 2. Paris, France.
  • 10
    Netzeva TI, Schultz TW. 2005. QSARs for the aquatic toxicity of aromatic aldehydes from Tetrahymena data. Chemosphere 61: 16321643.
  • 11
    Kar S, Harding AP, Roy K, Popelier PLA. 2010. QSAR with quantum topological molecular similarity indices: toxicity of aromatic aldehydes to Tetrahymena pyriformis. Sar Qsar Environ Res 21: 149168.
  • 12
    Johannsen FR, Levinskas GJ. 1986. Relationships between toxicity and structure of aliphatic nitriles. Fundam Appl Toxicol 7: 690697.
  • 13
    Lipnick RL. 1991. Outliers—Their origin and use in the classification of molecular mechanisms of toxicity. Sci Total Environ 109: 131153.
  • 14
    Office of Health and Environmental Assessment. 1987. The risk assessment guidelines of 1986. EPA/600/8-87/045. U.S. Environmental Protection Agency, Washington, DC.
  • 15
    Woutersen RA. 1998. Toxicologic profile of acrylonitrile. Scand J Work Environ Health 24: 59.
  • 16
    Feron VJ, Til HP, De Vrijer F, Woutersen RA, Cassee FR, Van Bladeren PJ. 1991. Aldehydes: Occurrence, carcinogenic potential, mechanism of action and risk assessment. Mutat Res Rev Mutat 259: 363385.
  • 17
    Gu XL, Mei B, Ma Q, Zhou W, Ni YM. 2005. Analysis of trace organic pollutants in coking-plant effluent. Sichuan Environ 24: 4446.
  • 18
    Jin LJ, Dai JY, Guo P, Wang LS, Wei ZB, Zhang Z. 1998. Quantitative structure-toxicity relationships for benzaldehydes to Daphnia magna. Chemosphere 37: 7985.
  • 19
    Joo SH, Mitch WA. 2007. Nitrile, aldehyde, and halonitroalkane formation during chlorination/chloramination of primary amines. Environ Sci Technol 41: 12881296.
  • 20
    Li Y, Yang WF, Li J. 2005. A survey of organic pollution in wastewater to HuanRiver. Arid Environ Monit 19: 204207.
  • 21
    Chen CY, Huang CF. 1996. Toxicity of organic mixtures containing cyanogenic toxicants. Environ Toxicol Chem 15: 14641469.
  • 22
    Chen CY, Yeh JT. 1996. Toxicity of binary mixtures of reactive toxicants. Environ Toxicol Water Qual 11: 8390.
  • 23
    Chen C, Lu C. 2002. An analysis of the combined effects of organic toxicants. Sci Total Environ 289: 123132.
  • 24
    Lin ZF, Zhang WH, Wang LS, Yu HX, Wu CD. 2003. Mechanism of the synergistic toxicity of malononitrile and p-nitrobenzaldehyde with Photobacterium phosphoreum. Toxicology Mechanisms and Methods 13: 241245.
  • 25
    Lin ZF, Niu XJ, Wu C, Yin KD, Cai ZP. 2005. Prediction of the toxicological joint effects between cyanogenic toxicants and aldehydes to Photobacterium phosphoreum. Qsar Comb Sci 24: 354363.
  • 26
    Lin ZF, Yin KD, Shi P, Wang LS, Yu HX. 2003. Development of QSARs for predicting the joint effects between cyanogenic toxicants and aldehydes. Chem Res Toxicol 16: 13651371.
  • 27
    Lin ZF, Wei D, Wang X, Yin K, Zhao D. 2004. Chemical-chemical interaction between cyanogenic toxicants and aldehydes: A mechanism-based QSAR approach to assess toxicological joint effects. Sar Qsar Environ Res 15: 127138.
  • 28
    Lin ZF, Kong DY, Zhong P, Yin KD, Dong LH. 2005. Influence of hydroxypropylcyclodextrins on the toxicity of mixtures. Chemosphere 58: 13011306.
  • 29
    Ribo JM, Kaiser KLE. 1987. Photobacterium phosphoreum toxicity bioassay. I. Test procedures and applications. Environ Toxicol Water Qual 2: 305323.
  • 30
    Finney D. 1971. Probit Analysis. Cambridge University Press, London, UK.
  • 31
    Broderius SJ, Kahl MD, Hoglund MD. 1995. Use of joint toxic response to define the primary mode of toxic action for diverse industrial organic chemicals. Environ Toxicol Chem 14: 15911605.
  • 32
    Zhang L, Zhou PJ, Yang F, Wang ZD. 2007. Computer-based QSARs for predicting mixture toxicity of benzene and its derivatives. Chemosphere 67: 396401.
  • 33
    Golbraikh A, Tropsha A. 2002. Beware of q2. J Mol Graph Model 20: 269276.
  • 34
    Bolboacă S-D, Jäntschi L. 2008. Modelling the property of compounds from structure: statistical methods for models validation. Environ Chem Lett 6: 175181.
  • 35
    Jaiswal M, Khadikar PV, Scozzafava A, Supuran CT. 2004. Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett 14: 32833290.
  • 36
    Castillo-Garit JA, Marrero-Ponce Y, Escobar J, Torrens F, Rotondo R. 2008. A novel approach to predict aquatic toxicity from molecular structure. Chemosphere 73: 415427.
  • 37
    Cheng XM, Shao H, Shan YL, Zhang ZH, Feng B, Wang LJ. 2007. Binding of formaldehyde and acrolein with human lymphoeytes DNA. Chin J Health Lab Technol 17: 2325.