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REFERENCES

  • 1
    Keiter S, Rastall A, Kosmehl T, Wurm K, Erdinger L, Braunbeck T, Hollert H. 2006. Ecotoxicological assessment of sediment, suspended matter and water samples in the upper Danube River. A pilot study in search for the causes for the decline of fish catches. Environ Sci Poll Res 13: 308319.
  • 2
    Keiter S, Grund S, Bavel B, Hagberg J, Engwall M, Kammann U, Kempt M, Manz W, Olsman H, Braunbeck T, Hollert H. 2008. Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube River. Anal Bioanal Chem 390: 20092019.
  • 3
    Maljevic E, Balac M. 2007. Determining of mineral oil-petroleum hydrocarbons in river sediments. Desalination 213: 135140.
  • 4
    Otte J, Andersson C, Abrahamson A, Olsman H, Keiter S, Engwall M, Hollert H, Brunstrom B. 2008. A bioassay approach to determine the dioxin-like activity in sediment extracts from the Danube River: Ethoxyresorufin-O-deethylase induction in gill filaments and liver of three-spiked sticklebacks (Gasterosteus aculeatus L.). Environ Intl 34: 11761184.
  • 5
    Boettcher M, Grund S, Keiter S, Kosmehl T, Reifferscheid G, Seitz N, Rocha PS, Hollert H, Braunbeck T. 2010. Comparison of in vitro and in situ genotoxicity in the Danube River by means of the comet assay and the micronucleus test. Mutat Re-Genetic Tox Environ Mutagenesis 700: 1117.
  • 6
    Grund S, Keiter S, Boettcher M, Seitz N, Wurm K, Manz W, Hollert H, Braunbeck T. 2010. Assessment of fish health status in the upper Danube River by investigation of ultrastructural alterations in the liver of barbel Barbus barbus. Dis Aquat Org 88: 235248.
  • 7
    Hollert H, Keiter S, Böttcher M, Grund S, Seitz N, Otte J, Bluhm K, Wurm K, Hecker M, Higley E, Giesy J, Takner H, van Bavel B, Engwall M, Reifferscheid G, Manz W, Erdinger L, Schulze T, Luebcke-van Varel U, Kammann U, Schöneberger R, Suter M, Brack W, Strähle U, Braunbeck T. 2009. Eine weight-of-evidence-studie zur bewertung der sedimentbelastung und des fischrückgangs in der oberen donau. Umweltwiss Schadst Forsch 21: 260263.
  • 8
    Monteiro P, Reis-henriques M, Coimbra J. 2000. Polycyclic aromatic hydrocarbons inhibit in vitro ovarian steroidogenesis in the flounder (Platichthys flesus L.). Aquat Toxicol 48: 549559.
  • 9
    Grund S, Higley E, Schonenberger R, Suter M, Giesy J, Braunbeck T, Hecker M, Hollert H. 2011. The endocrine disrupting potential of sediments from the upper Danube River (Germany) as revealed by in vitro bioassays and chemical analysis. Environ Sci Pollut Res 18: 446460.
  • 10
    Brack W. 2003. Effect-directed analysis: a promising tool for the identification of organic toxicants in complex mixtures? Anal Bioanal Chem 377: 397407.
  • 11
    Samoiloff M, Bell J, Birkholz D, Webster G, Arnott E, Pulak R, Madrid A. 1983. Combined bioassay chemical fractionation scheme for the determination and ranking of toxic-chemicals in sediments. Environ Sci Technol 17: 329334.
  • 12
    Schuetzle D, Lewtas J. 1986. Bioassy-directed chemical-analysis in environmental-research. Anal Chem 58: 1060A1075A.
  • 13
    Luebcke-von Varel U, Streck G, Brack W. 2008. Automated fractionation procedure for polycyclic aromatic compounds in sediment extracts on three coupled normal-phase high-performance liquid chromatography columns. J Chromatogr A 1185: 3142.
  • 14
    Brack W, Schirmer K, Erdinger L, Hollert H. 2005. Effect-directed analysis of mutagens and ethoxyresorufin-O-deethylase inducers in aquatic sediments. Environ Toxicol Chem 24: 24452458.
  • 15
    Hecker M, Hollert H. 2009. Effect-directed analysis (EDA) in aquatic ecotoxicology: State of the art and future challenges. Environ Sci Pollut Res 16: 607613.
  • 16
    Gazdar AF, Oie HK, Shackleton CH, Chen TR, Triche TJ, Myers CE, Chrousos GP, Brennan MF, Stein CA, La Rocca RV. 1990. Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis. Cancer Res 50: 54885496.
  • 17
    Hecker M, Newsted J, Murphy M, Higley E, Jones P, Wu R, Giesy J. 2006. Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effect on steroidogenesis: Hormone production. Toxicol Appl Pharmacol 217: 114124.
  • 18
    Sanderson JT. 2006. The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals. Toxicol Sci 94: 321.
  • 19
    Hecker M, Hollert H, Cooper R, Vinggaard AM, Akahori Y, Murphy M, Nellemann C, Higley E, Newsted J, Wu R, Lam P, Laskey J, Buckalew A, Grund S, Nakai M, Timm G, Giesy J. 2007. The OECD validation program of the H295R steroidogenesis assay for the identification of in vitro inhibitors and inducers of testosterone and estradiol production. Phase 2: Inter-laboratory pre-validation studies. Environ Sci Poll Res 14: 2330.
  • 20
    Hecker M, Giesy JP. 2008. Novel trends in endocrine disruptor testing: the H295R steroidogenesis assay for identification of inducers and inhibitors of hormone production. Anal Bioanal Chem 390: 287291.
  • 21
    Hecker M, Hollert H, Cooper R, Vinggaard AM, Akahori Y, Murphy M, Nellemann C, Higley E, Newsted J, Laskey J, Buckalew A, Grund S, Maletz S, Giesy J, Timm G. 2011. The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study. Environ Sci Poll Res 18: 503515.
  • 22
    Hollert H, Keiter S, Koenig N, Rudolf M, Ulrich M, Braunbeck T. 2003. A new sediment contact assay to assess particle-bound pollutants using zebrafish (Danio rerio) embryos. J Soils Sedim 3: 197207.
  • 23
    Chen G, White P. 2004. The mutagenic hazards of aquatic sediments: A review. Mutat Res 567: 151225.
  • 24
    Reifferscheid G, Arndt C, Schmid C. 2005. Further development of the beta-lactamase MutaGen assay and evaluation by comparison with Ames fluctuation tests and the umu test. Environ Mol Mutagen 46: 126139.
  • 25
    Seitz N, Bottcher M, Keiter S, Kosmehl T, Manz W, Hollert H, Braunbeck T. 2008. A novel statistical approach for the evaluation of comet assay data. Mutat Res 652: 3845.
  • 26
    Hollert H, Durr M, Holtey-Weber R, Islinger M, Brack W, Farber H, Erdinger L, Braunbeck T. 2005. Endocrine disruption of water and sediment extracts in a non-radioactive dot blot/RNAas protection-assay using isolated hepatocytes of rainbow trout. Deficiencies between bioanalytical effectiveness and chemically determined concentrations and how to explain them. Environ Sci Pollut Res 12: 347360.
  • 27
    Streck H, Schulze T, Brack W. 2008. Accelerated membrane-assisted clean-up as a tool for the clean-up of extracts from biological tissues. J Chromatogr A 1196–1197: 3340.
  • 28
    Mosman T. 1983. Rapid colometric assay for growth and survival: Application to proliferation and cytotoxicity. J Immunol Meth 65: 5563.
  • 29
    Grund S. 2010. A weight-of-evidence approach and bioassay-directed fractionations for investigation of the fish decline in the Upper Danube River. PhD thesis. University of Heidelberg, Heidelberg, Germany.
  • 30
    Schmitz HJ, Behnisch P, Hagenmaier A, Hagenmaier H, Bock KW, Schrenk D. 1996. CYP1A1-inducing potency in H4IIE cells and chemical composition of technical mixtures of polychlorinated biphenyls. Envion Toxicol Pharmacol 1: 7379.
  • 31
    Penning T, Burczynski M, Hung C, McCoull K, Palackal N, Tsuruda L. 1999. Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: Generation of reactive and redox active 0-quinones. Chem Res Toxicol 12: 118.
  • 32
    Luebcke-von Varel U, Machala M, Ciganek M, Neca J, Pencikova K, Palkova L, Vondracek J, Loeffler I, Streck G, Reifferscheid G, Flueckiger-Isler S, Weiss JM, Lamoree M, Brack W. 2011. Polar compounds dominate in vitro effects of sediment extracts. Environ Sci Technol 45: 23842390.
  • 33
    Bataineh M, Luebcke-von Varel U, Hayen H, Brack W. 2010. HPLC/APCI-FTICR-MS as a tool for identification of partial polar mutagenic compounds in effect-directed analysis. J Am Soc Mass Spec 21: 10161027.
  • 34
    Dellai A, Mansour H, Limem I, Bouhlel I, Sghaier M, Boubaker J, Ghedira K, Chekir-Ghedira L. 2009. Screening of antimutagenicity via antioxidant activity in different extracts from the flowers of phlomis crinita Cav. Ssp mauritanica munby from the center of Tunisia. Drug Chem Tox 32: 283292.
  • 35
    Paniagua-Perez R, Madrigal-Bujaidar E, Reyes-Cadena S, Alvarez-Gonzalez I, Sanchez-Chapul L, Perez-Gallaga J, Hernandez N, Flores-Mondragon G, Velasco O. 2008. Cell protection induced by beta-sitosterol: Inhibition of genotoxic damage, stimulation of lymphocyte production, and determination of its antioxidant capacity. Genotox Carcinogen 82: 615622.
  • 36
    Orrego R, McMaster M, Van der Kraak G, Holdway D. 2010. Effects of pulp and paper mill effluent extractives on aromatase CYP19a gene expression and sex steroid levels in juvenile triploid rainbow trout. Aquat Toxicol 97: 353360.
  • 37
    Nieminen P, Mustonen AM, Lindstrom-Seppa P, Asikainen J, Mussalo-Rauhamaa H, Kukkonen J. 2002. Phytosterols act as endocrine and metabolic disruptors in the European Polecat (Mustela putorius). Toxicol Appl Pharmacol 178: 2228.
  • 38
    Nakari T, Erkomaa K. 2003. Effects of phytosterols on zebrafish reproduction in multigeneration test. Environ Poll 123: 267273.
  • 39
    Chaloupka K, Krishnan V, Safe S. 1992. Polynuclear aromatic hydrocarbon carcinogens as antiestrogens in MCF-7 human breast cancer cells: Role of the Ah receptor. Carcinogen 13: 22332239.
  • 40
    Arcaro K, Yang Y, Gierthy J. 1999. Benzo[k]fluoranthene enhancement and suppression of 17β-estradiol catabolism in MCF-7 breast cancer cells. J Toxicol Environ Health 58: 413426.
  • 41
    He Y, Wiseman SB, Zhang X, Hecker M, Jones PD, Gamal El-Din M, Martin JW, Giesy JP. 2010. Ozonation attenuated the steroidogenic disruptive effects of sediment free oil sands process water in the H295R cell line. Chemosphere 80: 578584.