• 1
    Desbrow C, Routledge EJ, Brighty GC, Sumpter JP, Waldock M. 1998. Identification of estrogenic chemicals in STW effluent. 1. Chemical fractionation and in vitro biological screening. Environ Sci Technol 32: 15491558.
  • 2
    Korner W, Bolz U, Sussmuth W, Hiller G, Schuller W, Hanf V, Hagenmaier H. 2000. Input/output balance of estrogenic active compounds in a major municipal sewage plant in Germany. Chemosphere 40: 11311142.
  • 3
    Matsui S, Takigami H, Matsuda T, Taniguchi N, Adachi J, Kawami H, Shimizu Y. 2000. Estrogen and estrogen mimics contamination in water and the role of sewage treatment. Water Sci Technol 42: 173179.
  • 4
    Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT. 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000 : A national reconnaissance. Environ Sci Technol 36: 12021211.
  • 5
    Servos MR, Bennie DT, Burnison BK, Jurkovic A, McInnis R, Neheli T, Schnell A, Seto P, Smyth SA, Ternes TA. 2005. Distribution of estrogens, 17 beta-estradiol and estrone, in Canadian municipal wastewater treatment plants. Sci Total Environ 336: 155170.
  • 6
    Moreira DS, Aquino SF, Afonso R, Santos E, de Padua VL. 2009. Occurrence of endocrine disrupting compounds in water sources of Belo Horizonte Metropolitan Area, Brazil. Environ Technol 30: 10411049.
  • 7
    Gong J, Ran Y, Chen DY, Yang Y, Ma XX. 2009. Occurrence and environmental risk of endocrine-disrupting chemicals in surface waters of the Pearl River, South China. Environ Monit Assess 156: 199210.
  • 8
    Nakada N, Nyunoya H, Nakamura M, Hara A, Iguchi T, Takada H. 2004. Identification of estrogenic compounds in wastewater effluent. Environ Toxicol Chem 23: 28072815.
  • 9
    Ying G, Kookana RS, Kumar A, Mortimer M. 2009. Occurrence and implications of estrogens and xenoestrogens in sewage effluents and receiving waters from South East Queensland. Sci Total Environ 407: 51475155.
  • 10
    Swart N, Pool E. 2007. Rapid detection of selected steroid hormones from sewage effluents using an ELISA in the Kuils River water catchment area, South Africa. J Immunoassay Immunochem 28: 395408.
  • 11
    Johnson AC, Williams RJ, Simpson P, Kanda R. 2007. What difference might sewage treatment performance make to endocrine disruption in rivers? Environ Pollut 147: 194202.
  • 12
    Vermeirssen ELM, Suter MJF, Burkhardt-Holm P. 2006. Estrogenicity patterns in the Swiss midland river Lutzelmurg in relation to treated domestic sewage effluent discharges and hydrology. Environ Toxicol Chem 25: 24132422.
  • 13
    Vethaak AD, Lahr J, Schrap SM, Belfroid AC, Rijs GBJ, Gerritsen A, de Boer J, Bulder AS, Grinwis GCM, Kuiper RV, Legler J, Murk TAJ, Peijnenburg W, Verhaar HJM, de Voogt P. 2005. An integrated assessment of estrogenic contamination and biological effects in the aquatic environment of The Netherlands. Chemosphere 59: 511524.
  • 14
    Labadie P, Budzinski H. 2005. Determination of steroidal hormone profiles along the Jalle d'Eysines River (near Bordeaux, France). Environ Sci Technol 39: 51135120.
  • 15
    Baronti C, Curini R, D'Ascenzo G, Di Corcia A, Gentili A, Samperi R. 2000. Monitoring natural and synthetic estrogens at activated sludge sewage treatment plants and in a receiving river water. Environ Sci Technol 34: 50595066.
  • 16
    Barel-Cohen K, Shore LS, Shemesh M, Wenzel A, Mueller J, Kronfeld-Schor N. 2006. Monitoring of natural and synthetic hormones in a polluted river. J Environ Manage 78: 1623.
  • 17
    Anderson PD, D'Aco VJ, Shanahan P, Chapra SC, Buzby ME, Cunningham VL, Duplessie BM, Hayes EP, Mastrocco FJ, Parke NJ, Rader JC, Samuelian JH, Schwab BW. 2004. Screening analysis of human pharmaceuticals in U.S. surface waters. Environ Sci Technol 38: 838849.
  • 18
    Hannah R, D'Aco VJ, Anderson PD, Buzby ME, Caldwell DJ, Cunningham VL, Ericson JF, Johnson AC, Parke NJ, Samuelian JH, Sumpter JP. 2009. Exposure assessment of 17a-ethinylestradiol in surface waters of the United States and Europe. Environ Sci Technol 28: 27252732.
  • 19
    Williams RJ, Keller VD, Johnson AC, Young AR, Holmes MGR, Wells C, Gross-Sorokin M, Benstead RA. 2009. National risk assessment for intersex in fish arising from steroid estrogens. Environ Toxicol Chem 28: 220230.
  • 20
    Caldwell DJ, Mastrocco F, Hutchinson TH, Länge R, Heijerick D, Janssen C, Anderson PD, Sumpter JP. 2008. Derivation of an aquatic predicted no-effect concentration for the synthetic hormone, 17α-ethinyl estradiol. Environ Sci Technol 42: 70467054.
  • 21
    Caldwell DJ, Mastrocco F, Anderson PD, Länge R, Sumpter JP. 2012. Predicted-no-effect concentrations for the steroid estrogens estrone, 17β-estradiol, estriol, and 17α-ethinyl estradiol. Environ Toxicol Chem 31: 13961406 (this issue).
  • 22
    Kidd KA, Blanchfield PJ, Mills KH, Palace VP, Evans RE, Lazorchak JM, Flick RW. 2007. Collapse of a fish population after exposure to a synthetic estrogen. Proc Natl Acad Sci USA 104: 88978901.
  • 23
    Brown AR, Riddle AM, Winfield IJ, Fletcher JM, James JB. 2005. Predicting the effects of endocrine disrupting chemicals on healthy and disease impacted populations of perch (Perca fluviatilis). Ecol Model 189: 377395.
  • 24
    Higashitani T, Tamamoto H, Takahashi A, Tanaka H. 2003. Study of estrogenic effects on carp (Cyprinus carpio) exposed to sewage treatment plant effluents. Water Sci Technol 47: 93100.
  • 25
    Bjerregaard LB, Korsgaard B, Bjerregaard P. 2006. Intersex in wild roach (Rutilus rutilus) from Danish sewage effluent-receiving streams. Ecotoxicol Environ Saf 64: 321328.
  • 26
    Maltret-Geraudie P, Gerbron M, Minier C. 2008. Estrogenic response of wild roach from the Seine River (France). Cybium 32: 256257.
  • 27
    Tarrant H, Mousakitis G, Wylde S, Tattersall N, Lyons A, Maloney M, Llewellyn N. 2008. Raised plasma vitellogenin in male wild brown trout (Salmo trutta) near a wastewater treatment plant in Ireland. Environ Toxicol Chem 27: 17731779.
  • 28
    Jobling S, Nolan M, Tyler CR, Brighty G, Sumpter JP. 1998. Widespread sexual disruption in wild fish. Environ Sci Technol 32: 24982506.
  • 29
    Jobling S, Williams R, Johnson A, Taylor A, Gross-Sorokin M, Nolan M, Tyler CR, van Aerle R, Santos E, Brighty G. 2006. Predicted exposures to steroid estrogens in UK rivers correlate with widespread sexual disruption in wild fish populations. Environ Health Perspect 114: 3239.
  • 30
    Johnson AC, Williams RJ, Matthiessen P. 2006. The potential steroid hormone contribution of farm animals to freshwaters, the United Kingdom as a case study. Sci Total Environ 362: 166178.
  • 31
    Matthiessen P, Arnold D, Johnson AC, Pepper TJ, Pottinger TG, Pulman KGT. 2006. Contamination of headwater streams in the United Kingdom by oestrogenic hormones from livestock farms. Sci Total Environ 367: 616630.
  • 32
    Snyder EM, Snyder SA, Kelly KL, Gross TS, Villeneuve DL, Fitzgerald SD, Villalobos SA, Giesy JP. 2004. Reproductive responses of common carp (Cyprinus carpio) exposed in cages to influent of the Las Vegas Wash in Lake Mead, Nevada, from late winter to early spring. Environ Sci Technol 38: 63956395.
  • 33
    Woodling JD, Lopez EM, Maldonado TA, Norris DO, Vajda AM. 2006. Intersex and other reproductive disruption of fish in wastewater effluent dominated Colorado streams. Comp Biochem Physiol Part C: Toxicol Pharmacol 144: 1015.
  • 34
    Blazer VS, Iwanowicz LR, Iwanowicz DD. 2007. Intersex (testicular oocytes) in smallmouth bass from the Potomac River and selected nearby drainages. J Aquat Anim Health 19: 242253.
  • 35
    Vajda AM, Barber LM, Gray JL, Lopez EM, Woodling JD, Norris DO. 2008. Reproductive disruption in fish downstream from an estrogenic wastewater effluent. Environ Sci Technol 42: 34073414.
  • 36
    Hinck JE, Blazer VS, Schmitt CJ, Papoulias DM, Tillit DM. 2009. Widespread occurrence of intersex in black basses (Micropterus spp.) from U.S. rivers, 1995-2004. Aquat Toxicol (Amst) 95: 6070.
  • 37
    Johnson AC, Ternes T, Williams RJ, Sumpter JP. 2008. Assessing the concentrations of polar organic microcontaminants from point sources in the aquatic environment: Measure or model? Environ Sci Technol 42: 53905399.
  • 38
    Ort C, Hollender J, Schaerer M, Siegrist H. 2009. Model-based evaluation of reduction strategies for micropollutants from wastewater treatment plants in complex river networks. Environ Sci Technol 43: 32143220.
  • 39
    Johnson AC. 2010. Natural variations in flow are critical in determining concentrations of point source contaminants in rivers: An estrogen example. Environ Sci Technol 44: 78657870.
  • 40
    Thorpe KL, Cummings RL, Hutchinson TH, Scholer M, Brighty G, Sumpter JP, Tyler CR. 2003. Relative potencies and combination effects of steroidal estrogens in fish. Environ Sci Technol 37: 11421149.
  • 41
    Brian JV, Harris CA, Scholze M, Backhaus T, Booy P, Lamoree M, Pojana G, Jonkers N, Runnalls T, Bonfa A, Marcomini A, Sumpter JP. 2005. Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals. Environ Health Perspect 113: 721728.
  • 42
    Johnson A, Williams R. 2004. A model to estimate influent and effluent concentrations of estradiol, estrone, and ethinylestradiol at sewage treatment works. Environ Sci Technol 38: 36493658.
  • 43
    Williams RJ, Johnson AC, Keller V, Wells C, Holmes MGR, Young AR. 2008. Catchment risk assessment of steroid oestrogens from sewage treatment works. Science Report—SC030275/SR3. Environment Agency, Bristol, UK.
  • 44
    Sumpter JP, Johnson AC. 2008. 10th Anniversary perspective: Reflections on endocrine disruption in the aquatic environment: From known knowns to unknown unknowns (and many things in between). J Environ Monit 10: 14761485.
  • 45
    Harris CA, Brian JV, Pojana G, Lamoree M, Booy P, Marcomini A, Sumpter JP. 2009. The influence of a surfactant, linear alkylbenzene sulfonate, on the estrogenic response to a mixture of (xeno)estrogens in vitro and in vivo. Aquat Toxicol (Amst) 91: 9598.
  • 46
    Brian JV, Beresford N, Walker J, Pojana G, Fantinati A, Marcomini A, Sumpter JP. 2009. Hypoxia does not influence the response of fish to a mixture of estrogenic chemicals. Environ Sci Tech 43: 214218.