• 1
    Kreuger J. 1998. Pesticides in stream water within an agricultural catchment in southern Sweden, 1990–1996. Sci Total Environ 216:227251.
  • 2
    Wittmer IK, Bader HP, Scheidegger R, Singer H, Lück A, Hanke I, Carlsson C, Stamm C. 2010. Significance of urban and agricultural land use for biocide and pesticide dynamics in surface waters. Water Res 44:28502862.
  • 3
    Brock TCM, Alix A, Brown CD, Capri E, Gottesbüren B, Heimbach F, Lythgo CM, Schulz R, Streloke M. eds. 2010. Linking Aquatic Exposure and Effects. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA.
  • 4
    Reinert KH, Giddings JA, Judd L. 2002. Effects analysis of time-varying or repeated exposures in aquatic ecological risk assessment of agrochemicals. Environ Toxicol Chem 21:19771992.
  • 5
    Ashauer R, Boxall ABA, Brown CD. 2006. Predicting effects on aquatic organisms from fluctuating or pulsed exposure to pesticides. Environ Toxicol Chem 25:18991912.
  • 6
    Ashauer R, Wittmer I, Stamm C, Escher BI. 2011. Environmental risk assessment of fluctuating diazinon concentrations in an urban and agricultural catchment using toxicokinetic-toxicodynamic modeling. Environ Sci Technol 45:97839792.
  • 7
    Forum for Co-ordination of Pesticide Fate Models and Their Use (FOCUS). 2001. FOCUS surface water scenarios in the EU evaluation process under 91/414/EEC. Report prepared by the FOCUS Working Group on Surface Water Scenarios. European Commission, Health & Consumer Protection Directorate-General, Brussels, Belgium
  • 8
    Jager T, Albert C, Preuss TG, Ashauer R. 2011. General unified threshold model of survival: A toxicokinetic-toxicodynamic framework for ecotoxicology. Environ Sci Technol 45:25292540.
  • 9
    Ashauer R, Escher BI. 2010. Advantages of toxicokinetic and toxicodynamic modelling in aquatic ecotoxicology and risk assessment. J Environ Monitor 12:20562061.
  • 10
    Jager T. 2011. Some good reasons to ban ECx and related concepts in ecotoxicology. Environ Sci Technol 45:81808181.
  • 11
    Jager T, Heugens EHW, Kooijman SALM. 2006. Making sense of ecotoxicological test results: Towards application of process-based models. Ecotoxicology 15:305314.
  • 12
    Ashauer R, Agatz A, Albert C, Ducrot V, Galic N, Hendriks J, Jager T, Kretschmann A, O'Connor I, Rubach MN, Nyman A-M, Schmitt W, Stadnicka J, Van den Brink PJ, Preuss TG. 2011. Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: A brief discussion of concepts. Environ Toxicol Chem 30:25192524.
  • 13
    Ashauer R, Hintermeister A, Caravatti I, Kretschmann A, Escher BI. 2010. Toxicokinetic-toxicodynamic modeling explains carry-over toxicity from exposure to diazinon by slow organism recovery. Environ Sci Technol 44:39633971.
  • 14
    Ashauer R, Boxall ABA, Brown CD. 2007. New ecotoxicological model to simulate survival of aquatic invertebrates after exposure to fluctuating and sequential pulses of pesticides. Environ Sci Technol 41:14801486.
  • 15
    Stadnicka J, Schirmer K, Ashauer R. 2012. Predicting concentrations of organic chemicals in fish by using toxicokinetic models. Environ Sci Technol 46:32733280.
  • 16
    Hommen U, Ashauer R, Van den Brink P, Caquet T, Ducrot V, Lagadic L, Ratte HT. 2010. Extrapolation methods in aquatic effects assessment of time-variable exposures to pesticides. In Brock TCM, Alix A, Brown CD, Capri E, Gottesbüren B, Heimbach F, Lythgo CM, Schulz R, Streloke M, eds, Linking Aquatic Exposure & Effects in the Risk Assessment of Pesticides. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, pp 211242.
  • 17
    Altenburger R, Greco WR. 2009. Extrapolation concepts for dealing with multiple contamination in environmental risk assessment. Integr Environ Assess Manag 5:6268.
  • 18
    Ashauer R, Boxall ABA, Brown CD. 2007. Modeling combined effects of pulsed exposure to carbaryl and chlorpyrifos on Gammarus pulex. Environ Sci Technol 41:55355541.
  • 19
    Nyman A-M, Schirmer K, Ashauer R. 2012. Toxicokinetic-toxicodynamic modelling of survival of Gammarus pulex in multiple pulse exposures to propiconazole: Model assumptions, calibration data requirements and predictive power. Ecotoxicology 21:18281840.
  • 20
    Ashauer R. 2010. Toxicokinetic-toxicodynamic modelling in an individual based context—Consequences of parameter variability. Ecol Model 221:13251328.
  • 21
    Zhao Y, Newman MC. 2007. The theory underlying dose–response models influences predictions for intermittent exposures. Environ Toxicol Chem 26:543547.
  • 22
    Kooijman SALM, Bedaux JJM. 1996. Some statistical properties of estimates of no-effect concentrations. Water Res 30:17241728.
  • 23
    Organisation for Economic Co-operation and Development (OECD). 1992. OECD guidelines for testing chemicals 210: Fish, early-life stage toxicity test. Paris, France.
  • 24
    Ashauer R, Boxall ABA, Brown CD. 2007. Simulating toxicity of carbaryl to Gammarus pulex after sequential pulsed exposure. Environ Sci Technol 41:55285534.
  • 25
    Ashauer R, Brown CD. 2007. Comparison between FOCUS output for pesticide concentrations over time and field observations. Report for DEFRA project DS 3321. The University of York, York, UK.
  • 26
    McKim JM. 1977. Evaluation of tests with early life stages of fish for predicting long-term toxicity. J Fish Res Board Can 34:11481154.