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A single-parameter logistic equation for fitting concentration-response curves from standard acute ecotoxicity assays


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A set of 69 concentration–response curves from 5 acute ecotoxicity assays was fitted with a 2-parameter logistic equation. High correlation between values of regression parameters suggested similar slopes of the curves. This enabled derivation of the empirical single-parameter logistic equation with the sole median effective concentration (EC50) parameter. Such an equation might be useful in the evaluation of lower-quality (preliminary) experimental data and for the reduction of the number of test organisms and of testing costs. Environ Toxicol Chem 2013;32:2412–2416. © 2013 SETAC

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