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Toxicokinetics of chlorobenzenes in fish

Authors

  • Geertjan Van Hoogen,

    1. Laboratory of Environmental and Toxicological Chemistry, University of Amsterdam, 1018 WV Amsterdam, The Netherlands
    Current affiliation:
    1. Environmental Laboratory, City of Amsterdam, 1075 XJ, Amsterdam
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  • Antoon Opperhuizen

    Corresponding author
    1. Laboratory of Environmental and Toxicological Chemistry, University of Amsterdam, 1018 WV Amsterdam, The Netherlands
    • Laboratory of Environmental and Toxicological Chemistry, University of Amsterdam, 1018 WV Amsterdam, The Netherlands
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Abstract

In acute toxicity tests with guppies (Poecilia reticulata), lethal effects were found for 1,2,3-tri-, 1,2,3,4-tetra-, and pentachlorobenzene if the concentrations in the fish approached 2.0 to 2.5 μmol/g fish. The lethal concentrations were equal for the three test compounds and were independent of the exposure conditions. The lethal concentrations of chlorobenzenes in guppies were equal to those previously found for polychlorinated biphenyls in goldfish but approximately two times higher than those found for chlorinated phenols in goldfish. Combinations of the exposure times and exposure concentrations causing mortality can be described and readily predicted with a first-order bioconcentration model.

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