• 1
    Kavlock RJ, et al. 1996. Research needs for risk assessment of health and environmental effects of endocrine disruptors: A report of the U.S. EPA-sponsored workshop. Environ Health Perspect 104: 715740.
  • 2
    European Community. 1997. European Workshop on the Impact of Endocrine Disrupters on Human Health and Wildlife. Workshop Publication EUR 17549. Paris, France.
  • 3
    Society of Environmental Toxicology and Chemistry–Europe. 1998. SETAC–Europe/OECD/EC Expert Workshop on Endocrine Modulators, Wildlife-Assessment and Testing. SETAC–Europe Press, Brussels, Belgium (in press).
  • 4
    Safe SH. 1995. Do environmental estrogens play a role in development of breast cancer in women and male reproductive problems. Hum Ecol Risk Assess 1: 1724.
  • 5
    vom Saal FS. 1995. Environmental estrogenic chemicals: Their impact on embryonic development. Hum Ecol Risk Assess 1: 316.
  • 6
    Ankley GT, Giesy JP. 1998. Endocrine disruptors in wildlife: A weight of evidence perspective. In KendallR, DickersonR, SukW, GiesyJ, eds, Principles and Processes for Assessing Endocrine Disruption in Wildlife. SETAC, Pensacola, FL, USA (in press).
  • 7
    Purdom CE, Hardiman PA, Bye VJ, Eno NC, Tyler CR, Sumpter JP. 1994. Estrogenic effects of effluents from sewage treatment works. Chem Ecol 8: 275285.
  • 8
    Folmar LC, Denslow ND, Rao V, Chow M, Crain DA, Enblom J, Marcino J, Guillette LJ, Jr. 1996. Vitellogenin induction and reduced serum estosterone concentrations in feral male carp (Cyprinus carpio) captured near a major metropolitan sewage treatment plant. Environ Health Perspect 104: 10961101.
  • 9
    Bortone SA, Davis WB, Bundrick CM. 1989. Morphological and behavioral characters in mosquitofish as a potential bioindication of exposure to kraft mill effluent. Bull Environ Contam Toxicol 43: 370377.
  • 10
    Bortone SA, Davis WB. 1994. Fish intersexuality as an indicator of environmental stress. BioScience 44: 165172.
  • 11
    McMaster ME, Van Der Kraak GJ, Munkittrick KR. 1996. An epidemiological evaluation of the biochemical basis for steroid hormonal depressions in fish exposed to industrial wastes. J Great Lakes Res 22: 153171.
  • 12
    Van Der Kraak GJ, Munkittrick KR, McMaster ME, MacLatchy DM. 1998. A comparison of bleached kraft pulp mill effluent, 17β-estradiol and β-sitosterol effects on reproductive function in fish. In KendallR, DickersonR, SukW, GiesyJ, eds, Principles and Processes for Evaluating Endocrine Disruption in Wildlife. SETAC, Pensacola, FL, USA (in press).
  • 13
    Guillette LJ, Gross TS, Masson GR, Matter MM, Percival HF, Woodward AR. 1994. Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida. Environ Health Perspect 102: 680688.
  • 14
    Bryan GW, Gibbs PE, Hummerstone LG, Burt GR. 1986. The decline of the gastropod Nucella lapillus around south-west England: Evidence for the effect of tributyltin from antifouling paints. J Mar Biol Assoc UK 66: 611640.
  • 15
    Fent K. 1996. Ecotoxicology of organotin compounds. Crit Rev Toxicol 26: 1117.
  • 16
    Ankley GT, Johnson RD, Detenbeck NE, Bradbury SP, Toth G, Folmar LC. 1997. Development of a research strategy for assessing the ecological risk of endocrine disruptors. Rev Toxicol 1: 231267.
  • 17
    ColbornT, ClementC, eds. 1992. Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection. Princeton Scientific, Princeton, NJ, USA.
  • 18
    Colborn T, Dumanoski D, Meyers JP. 1996. Our Stolen Future: Are We Threatening Our Fertility, Intelligence, and Survival? A Scientific Detective Story. Dutton, New York, NY, USA.
  • 19
    U.S. Environmental Protection Agency. 1996. Strategic plan for the Office of Research and Development. EPA/600/R3–91–063. Washington, DC.
  • 20
    U.S. Environmental Protection Agency. 1997. Special report on environmental endocrine disruption: An effects assessment and analysis. EPA 630/R–96–012. Washington, DC.
  • 21
    Gray LE, et al. 1998. Endocrine screening methods workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor and steroidogenic enzyme mechanisms. Reprod Toxicol (in press).
  • 22
    Zeeman M, Auer CM, Clements RG, Boethling RS. 1995. U.S. EPA regulatory practices on the use of QSAR for new and existing chemical evaluations. SAR QSAR Environ Res 3: 179201.
  • 23
    Commission of the European Communities. 1996. Technical Guidance Document in Support of Directive 93/67/ECC on Risk Assessment for New Notified Substances and Commission Regulation 1488/94, Risk Assessment for Existing Substances. Office for Official Publications of the European Communities, Luxembourg, Belgium.
  • 24
    vom Saal FS, et al. 1997. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbesterol and opposite effects at high doses. Proc Natl Acad Sci USA 94: 20562061.
  • 25
    Mackay JM. 1995. Dose selection in in vivo genetic toxicology assays. Environ Mol Mutagen 25: 323327.
  • 26
    Jha AN, Hutchinson TH, Elliott BM, Mackay JM, Dixon DR. 1998. Evaluation of the genotoxicity of municipal sewage effluent using the marine worm Platynereis dumerilii (Polychaeta: Nereidae). Mutat Res (in press).
  • 27
    Norris DO. 1996. Vertebrate Endocrinology. Academic, San Diego, CA, USA.
  • 28
    Van Der Kraak GJ, Zacharewski T, Janz D, Sanders B, Gooch J. 1998. Comparative endocrinology and mechanisms of endocrine modulation in fish and wildlife. In KendallR, DickersonR, SukW, GiesyJ, eds, Principles and Processess for Evaluating Endocrine Disruption in Wildlife. SETAC, Pensacola, FL, USA (in press).
  • 29
    Kavlock RJ, Ankley GT. 1996. A perspective on the risk assessment process for endocrine-disruptive effects on wildlife and human health. Risk Anal 16: 731739.
  • 30
    Kime DE. 1987. The steroids. In Chester-JonesI, IngletonPM, PhillipsJG, eds, Fundamentals of Comparative Vertebrate Endocrinology. Plenum, New York, NY, USA.
  • 31
    Fry MF. 1995. Reproductive effects in birds exposed to pesticides and industrial chemicals. Environ Health Perspect 103: 165171.
  • 32
    Ronis MJJ, Walker CH. 1985. Species variations in the metabolism of liposoluble organochlorine compounds by hepatic microsomol monooxygenase: Comparative kinetics in four vertebrate species. Comp Biochem Physiol C 82: 445449.
  • 33
    Wallace KB. 1989. Glutathione-dependent metabolism in fish and rodents. Environ Toxicol Chem 8: 10491055.
  • 34
    Petit F, Valotaire Y, Pakdel F. 1995. Differential functional activities of rainbow trout and human estrogen receptors expressed in the yeast Saccharomyces cerevisiae. Eur J Biochem 223: 584592.
  • 35
    Gustafsson J-A. 1996. Characteristics and function of a novel estrogen receptor β. Proceedings, Steriod Receptor Superfamily Symposium, University of Wisconsin, Madison, WI, USA, September 27–29.
  • 36
    Vonier PM, Crain DA, McLachlan JA, Guillette LJ, Arnold SF. 1996. Interaction of environmental chemicals with the estrogen and progesterone receptors from the oviduct of the American alligator. Environ Health Perspect 104: 13181322.
  • 37
    Zacharewski T. 1997. In vitro bioassays for assessing estrogenic substances. Environ Sci Technol 31: 613623.
  • 38
    Ankley GT, Bradbury SP, Hermens J, Mekenyan O, Tollefson K-E. 1998. Current approaches to the use of structure activity relationships (SARs) in identifying the hazards of endocrine disrupting chemicals to wildlife. In Society of Environmental Toxicology and Chemistry-Europe/OECD/EC Expert Workshop on Endocrine Modulators, Wildlife-Assessment and Testing. SETAC-Europe Press, Brussels, Belgium (in press).
  • 39
    Eroschenko VP, Palmiter RD. 1980. Estrogenicity of kepone in birds and mammals. In McLachlanJA, ed, Estrogens in the Environment. Elsevier, New York, NY, USA, pp 305325.
  • 40
    Thomas P, Smith J. 1993. Binding of xenobiotics to the estrogen receptor of spotted seatrout: A screening assay for potential estrogenic effects. Mar Environ Res 35: 147151.
  • 41
    Lazier CB, Lonergan K, Mommsen TP. 1985. Hepatic estrogen receptors and plasma estrogen-binding affinity in the Atlantic salmon. Gen Comp Endocrinol 70: 334344.
  • 42
    Riley D, Callard IP. 1988. An estrogen receptor in the liver of the viviparous watersnake, Nerodia; characterization and seasonal changes in binding capacity. Endocrinology 123: 753761.
  • 43
    Pottinger TG. 1988. Seasonal variation in specific plasma and target tissue binding of androgens, relative to steroid levels, in the brown trout. Gen Comp Endocrinol 70: 334344.
  • 44
    Smith JS, Thomas P. 1991. Changes in the hepatic estrogen receptor concentrations during the annual reproductive and ovarian cycle of a marine teleost, the spotted seatrout. Gen Comp Endocrinol 81: 234245.
  • 45
    Yu MS, Ho S-M. 1989. Seasonal variation in hepatic binding of estrogen in the turtle, Chrysemys picta. Gen Comp Endocrinol 75: 472480.
  • 46
    Campbell PM, Pottinger TG, Sumpter JP. 1994. Changes in the affinity of estrogen and androgen receptors accompany changes in receptor abundance in brown and rainbow trout. Gen Comp Endocrinol 94: 329340.
  • 47
    Soto AM, Lin T, Justicia H, Silvia RM, Sonnenschein C. 1992. An “in culture” bioassay to assess the estrogenicity of xenobiotics (E-Screen). In ColbornT, ClementC, eds, Chemically Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection. Princeton Scientific, Princeton, NJ, USA, pp 295309.
  • 48
    Zacharewski TR, Berhane K, Gillesby BE, Burnison BK. 1995. Detection of estrogen- and dioxin-like activity in pulp and paper mill black liquor and effluent using in vitro recombinant receptor/reporter gene assays. Environ Sci Technol 29: 21402146.
  • 49
    Routledge EJ, Sumpter JP. 1996. Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen. Environ Toxicol Chem 15: 218248.
  • 50
    McMaster ME, Van Der Kraak GJ, Munkittrick KR. 1996. Exposure to bleached kraft pulp mill effluent reduces the steroid biosynethic capacity of white sucker ovarian follicles. Comp Biochem Physiol C 112: 169178.
  • 51
    Waller CL, Minor DL, Geisey JP, McKinney D. 1995. Using three-dimensional quantitative structure-activity relationships to examine estrogen receptor binding affinities of polychlorinated hydroxybiphenyls. Environ Health Perspect 103: 702707.
  • 52
    Waller CL, Juma B, Gray LE, Kelce W. 1996, Three-dimensional quantitative structure-activity relationships for androgen receptor ligands. Toxicol Appl Pharmacol 137: 219227.
  • 53
    Waller CL, et al. 1996. Ligand-based identification of environmental estrogens. Chem Res Toxicol 9: 12401248.
  • 54
    Bradbury SP, Mekenyan OG, Ankley GT. 1996. Quantitative structure activity relationships for polychlorinated hydroxybiphenyl estrogen receptor binding affinity: An assessment of conformer flexibility. Environ Toxicol Chem 15: 19451954.
  • 55
    Mekenyen OG, Ivanov JM, Karabunarliev S, Bradbury SP, Ankley GT, Karcher W. 1998. A computationally-based hazard identification algorithm that incorporates ligand flexibility. I. Identification of potential androgen receptor ligands. Environ Sci Technol (in press).
  • 56
    Facemire CF, Cross TS, Guillette LJ, Jr. 1996. Reproductive impairment in the Florida panther: Nature or nurture? Environ Health Perspect 103: 7986.
  • 57
    Henny C, Grove R, Hedstrom O. 1996. Hypoplastic reproductive organs related to xenobiotic compounds in young male river otter from Columbia River. Abstracts, 17th Annual Meeting, Society of Environmental Toxicology and Chemistry, Washington, DC, USA, November 17–21, p 18.
  • 58
    Giesy JP, et al. 1994. Contaminants in fishes from Great Lakes- influenced sections and above dams on three Michigan Rivers: II. Implications for the health of mink. Arch Environ Contam Toxicol 27: 213223.
  • 59
    Giesy JP, et al. 1994. Contaminants in fishes from Great Lakes- influenced sections and above dams on three Michigan Rivers: 1. Concentrations of organochlorine insecticides, PCBs, dioxin equivalents and mercury. Arch Environ Contam Toxicol 27: 202212.
  • 60
    Heaton SN, et al. 1995. Dietary exposure of mink to carp from Saginaw Bay. I. Effects on reproduction and survival and potential risks to wild mink populations. Arch Environ Contam Toxicol 28: 334343.
  • 61
    Tillitt DE, et al. 1995. Dietary exposure to carp from Saginaw Bay. III: Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification. Environ Sci Technol 30: 282291.
  • 62
    Adams NR. 1995. Detection of the effects of phytoestrogens on sheep and cattle. J Anim Sci 73: 15091515.
  • 63
    Setchell BP, Cox JE. 1982. Secretion of free and conjugated steroids by the horse testis into lymph and venous blood. J Reprod Fertil 32 (Suppl.): 123127.
  • 64
    Bhavnani BR, Woolever CA. 1991. Interaction of ring B unsaturated estrogens with estrogen receptors of human endometrium and rat uterus. Steroids 56: 201210.
  • 65
    Raeside JI, Wilkinson CR, Farkas G. 1993. Ontogenesis of estrogen secretion by porcine fetal testes. Acta Endocrinol 128: 549554.
  • 66
    Aulerich RJ, Bleavins MR. 1991. Potential of mink as an animal model in testing in the area of toxicology. In BLamb, ed, Blue Book of Fur Farming. Comm Marketing, Eden Prairie, MN, USA, pp 3032.
  • 67
    Harries JE, et al. 1996. A survey of estrogenic activity in United Kingdom inland waters. Environ Toxicol Chem 15: 19032002.
  • 68
    Goodbred SL, Gilliom RJ, Gross TS, Denslow NP, Bryant WL, Schoeb TR. 1997. Reconnaissance of 17-β estradiol, 11-ketotestosterone, vitellogenin, and gonad histopathology in common carp of United States streams: Potential for contaminant-induced endocrine disruption. Report 96–627. U.S. Geology Survey, Denver, CO.
  • 69
    Janssen PAH, Lambert JGD, Goos HJTh. 1995. The annual ovarian cycle and influence of pollution on vitellogenesis in the flounder, Platichthys flesus. J Fish Biol 47: 409523.
  • 70
    Lye CM, Frid CL, Gill ME, McCormick D. 1997. Abnormalities in the reproductive health of flounder, Platichthys flesus, exposed to effluent from a sewage treatment works. Mar Pollut Bull 34: 3441.
  • 71
    Munkittrick KR, Portt CB, Van Der Kraak GJ, Smith IR, Rokosh D. 1991. Impact of bleached kraft mill effluent on population characteristics, liver MFO activity and serum steroid levels of a Lake Superior white sucker (Catostomus commersoni) population. Can J Fish Aquat Sci 48: 13711380.
  • 72
    Van Der Kraak GJ, Munkittrick KR, Portt CB, Chang JP. 1992. Exposure to bleached pulp mill effluent disrupts the pituitary gonadal axis at multiple sites. Toxicol Appl Pharmacol 115: 224233.
  • 73
    Redding JM, Patino R. 1993. Reproductive physiology. In EvansDH, ed, The Physiology of Fishes. CRC, Boca Raton, FL, USA, pp 503540.
  • 74
    Van Der Kraak GJ, Chang JP, Janz DM. 1998. Reproduction. In DHEvans, ed, The Physiology of Fishes, 2nd ed. CRC, Boca Raton, FL, USA (in press).
  • 75
    Kawauchi H, Suzuki K, Hoh H, Swanson P, Nozaki M, Naito N, Nagahama Y. 1989. Quality of salmon pituitary gonadotropins. Fish Physiol Biochem 7: 2938.
  • 76
    Pinter J, Thomas P. 1995. Characterization of a progestogen receptor in the ovary of the spotted seatrout, Cynoscion nebulosus. Biol Reprod 52: 667675.
  • 77
    Pinter J, Thomas P. 1997. The ovarian progestogen receptor in the spotted seatrout, Cynoscion nebulosus, demonstrates steroid specificity different from progesterone receptors in other vertebrates. J Steroid Biochem Mol Biol 60: 113119.
  • 78
    Arai R. 1967. Androgenic effects of 11-ketotestosterone on some sexual characteristics in the teleost Oryzias latipes. Annot Zool Jpn 40: 15.
  • 79
    Idler DR, Schmidt PJ, Biely J. 1961. The androgenic activity of 11-ketotestosterone, a steroid in salmon plasma. Can J Biochem Physiol 39: 317320.
  • 80
    Idler DR, Reinboth R, Walsh JM, Truscott B. 1976. A comparison of 11-hydroxytestosterone and 11-ketotestosterone in blood of ambisexual and gonochoristic teleosts. Gen Comp Endocrinol 30: 517521.
  • 81
    Foster A, Jalabert B, Billard R, Breton B, Zohar Y. 1983. The gonadal steroids. In HoarWS, RandallGJ, DonaldsonEM, eds, Fish Physiology, Vol. 9. Academic, New York, NY, USA, pp 277372.
  • 82
    Takahashi H. 1977. Juvenile hermaphroditism in the zebrafish, Brachydanio rerio. Bull Fac Fish Hokkaido Univ 28: 5765.
  • 83
    Shapiro DY. 1994. Sex change in fishes—How and why? In ShortRV, BalabanE, eds, The Differences Between the Sexes. Cambridge University Press, Cambridge, UK, pp 105130.
  • 84
    Hunter GA, Donaldson EM. 1983. Hormonal sex control and its application to fish culture. In HoarWS, RandallDJ, DonaldsonEM, eds, Fish Physiology, Vol. 9-Reproduction, Part B: Behavior and Fertility Control. Academic, Orlando, FL, USA, pp 223303.
  • 85
    Goudie CA, Redner BD, Simco BA, Davis KB. 1983. Feminization of channel catfish by oral administration of steroid sex hormones. Trans Am Fish Soc 12: 670672.
  • 86
    Davis KB, Simco BA, Goudie CA. 1991. Genetic and hormonal control of sex determination in channel catfish. In Scott AP, Sumpter JP, Kime DE, Wolfe MS, eds, Proceedings, 4th International Symposium on the Reproductive Physiology of Fish, University of East Anglia, Norwich, UK, July 7–12, pp 244246.
  • 87
    Yamamoto TS. 1975. Medaka (Killifish) Biology and Strains. Stock Culture in Biological Field Series. Keigaku Publishing, Tokyo, Japan.
  • 88
    Gray MA, Metcalfe CD. 1996. Induction of testis-ova in Japanese medaka (Oryzias latipes) exposed to p-nonylphenol. Environ Toxicol Chem 16: 10821086.
  • 89
    Turner CL. 1942. A quantitative study of the effects of different concentrations of ethynyl testosterone and methyl testosterone in the production of gonopodia in females of Gambusia affinis. Physiol Zool 15: 263280.
  • 90
    Miles-Richardson S, Fitzgerald S, Render J, Kramer V, Giesy J. 1996. Pathological effects of 17β-estradiol on the reproductive system of fathead minnows (Pimephales promelas). Abstracts, 17th Annual Meeting, Society of Environmental Toxicology and Chemistry, Washington, DC, USA, November 17–21, p 216.
  • 91
    Papoulias DM, Tillitt DE, Jones S, Noltie D. 1995. Use of medaka (Oryzias latipes) as a model to identify reproductive endpoints indicative of exposure to endocrine disrupting chemicals. Abstracts, 16th Annual Meeting, Society of Environmental Toxicology and Chemistry Vancouver, BC, Canada, November 5–9, p 187.
  • 92
    U.S. Environmental Protection Agency. 1986. Ecological risk assessment. Hazard evaluation division standard evaluation procedure. EPA 540/19–83–001. Washington, DC.
  • 93
    U.S. Environmental Protection Agency. 1989. Pesticide assessment guidelines. Subdivision E, hazard evaluation: Wildlife and aquatic organisms. EPA 540/09–82–024. Washington, DC.
  • 94
    U.S. Environmental Protection Agency. 1994. Short-term methods for estimating the chronic toxicity of effluents and receiving waters to freshwater organisms, 3rd ed. EPA 600/4–91–002. Cincinnati, OH.
  • 95
    U.S. Environmental Protection Agency. 1994. Short-term methods for estimating the chronic toxicity of effluents and receiving waters to marine and estuarine organisms. EPA 600/4–91–003. Cincinnati, OH.
  • 96
    Organization for Economic Cooperation and Development. 1992. OECD guidelines for testing of chemicals. Section 2. Guideline 203. Fish acute toxicity test. Paris, France.
  • 97
    Organization for Economic Cooperation and Development. 1992. Guidelines for testing of chemicals. Section 2. Guideline 204. Fish early-life stage toxicity test. Paris, France.
  • 98
    Organization for Economic Cooperation and Development. 1992. OECD guidelines for testing of chemicals. Section 2. Guideline 210. Fish early-life stage toxicity test. Paris, France.
  • 99
    U.S. Environmental Protection Agency. 1972. Recommended bioassay procedure for brook trout Salvelinus fontinalis (Mitchill) partial chronic tests. Duluth, MN.
  • 100
    U.S. Environmental Protection Agency. 1982. User's guide for conducting life-cycle chronic toxicity tests with fathead minnows (Pimephales promelas). EPA 600/8–81–011. Duluth, MN.
  • 101
    U.S. Environmental Protection Agency. 1991. Guidelines for conducting early life stage toxicity tests with Japanese medaka (Orvzias latipes). EPA 600/3–01–063. Duluth, MN.
  • 102
    Herman RL, Kincaid HL. 1988. Pathological effects of orally administered estradiol to rainbow trout. Aquaculture 72: 165172.
  • 103
    Jobling S, Sheahan D, Osborne JA, Matthiessen P, Sumpter JP. 1996. Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Environ Toxicol Chem 15: 194202.
  • 104
    Laenge R, Schweinfurth H, Croudace CP, Panter GH. 1997. Growth and reproduction of fathead minnow (Pimephales promelas) exposed to the synthetic steroid hormone ethynylestradiol in a life-cycle test. Abstracts, 7th Annual Meeting, Society of Environmental Toxicology and Chemistry-Europe, Amsterdam, The Netherlands, April 7–10, p 43.
  • 105
    Donohoe RM, Curtis LR. 1996. Estrogenic activity of chlordecone, o,p'-DDT and o,p'-DDE in juvenile rainbow trout: Induction of vitellogenesis and interaction with hepatic estrogen binding sites. Aquat Toxicol 36: 3152.
  • 106
    Nimrod AC, Benson WH. 1998. Assessment of estrogenic activity in fish. In RollandR, ed, Chemically-Induced Alterations in the Functional Development and Reproduction of Fishes. SETAC, Pensacola, FL, USA (in press).
  • 107
    Lech JJ, Lewis SK, Ren L. 1996. In vivo estrogenic activity of nonylphenol in rainbow trout. Fundam Appl Toxicol 30: 229232.
  • 108
    Craik JCA, Harvey SM. 1984. A biochemical method for distinguishing between the sexes of fishes by the presence of yolk protein in the blood. J Fish Biol 25: 293303.
  • 109
    Mommsen TP, Walsh PJ. 1988. Vitellogenesis and oocyte assembly. In WSHoar, RandallVJ, eds, Fish Physiology, Vol. XIA. Academic, San Diego, CA, USA, pp 347406.
  • 110
    Jobling S, Sumpter JP. 1993. Detergent components in sewage effluent are weakly estrogenic to fish: An in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol 27: 361372.
  • 111
    Pelissero C, Flouriot G, Foucher JL, Bennetau B, Dunoguès J, Le Gac F, Sumpter JP. 1993. Vitellogenin synthesis in cultured hepatocytes: An in vitro test for the estrogenic potency of chemicals. J Steroid Biochem Mol Biol 44: 263272.
  • 112
    Sumpter JP. 1985. The purification, radioimmunoassay and plasma levels of vitellogenin from the rainbow trout, Salmo gairdneri. In LoftsB, HolmersWH, eds, Trends in Comparative Endocrinology. Hong Kong University Press, Hong Kong, pp 355357.
  • 113
    Denslow ND, Chow MM, Folmar LC, Bonomelli S, Heppell SA, Sullivan CV. 1996. Development of antibodies to teleost vitellogenins: Potential biomarkers for environmental estrogens. In BengtsonDA, HenshelDS, eds, Environmental Toxicology and Risk Assessment, Vol 5, STP 1306. American Society for Testing and Materials, Conshohocken, PA, pp 2336.
  • 114
    Tyler CR, van der Eerden B, Jobling S, Panter GH, Sumpter JP. 1996. Measurement of vitellogenin, a biomarker for exposure to estrogenic chemicals, in a wide variety of cyprinid fish. J Comp Physiol B 166: 418426.
  • 115
    Trudeau VL, Wade MG, Van Der Kraak GJ, Peter RE. 1993. Effects of 17β-estradiol on pituitary and testicular function in male goldfish. Can J Zool 71: 11311136.
  • 116
    Zohar Y, Pagelson G, Tosky M. 1988. Daily changes in reproductive hormone levels in the female gilthead seabream Sparus aurata at the spawning period. Colloq INRA 44: 119125.
  • 117
    Matsuyama M, Adachi S, Nagahama Y, Matsuura S. 1990. Diurnal rhythm of oocyte development and plasma steroid hormone levels in the female red sea bream, Pagrus major, during the spawning season. Aquaculture 73: 357372.
  • 118
    Tremblay L, Yao X, Van Der Kraak GJ. 1995. Interactions of the environmental estrogens nonylphenol and β-sitosterol with liver estrogen receptors in fish. Proceedings, 5th International Symposium on the Reproductive Physiology of Fish, Austin, TX, USA, July 2–8, p 202.
  • 119
    White R, Jobling S, Hoare SA, Sumpter JP, Parker MG. 1994. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135: 175182.
  • 120
    Ghosh S, Thomas P. 1995. Antagonistic effects of xenobiotics on steroid-induced final maturation of Atlantic croaker oocytes in vitro. Mar Environ Res 39: 159163.
  • 121
    Howell WM, Blank DA, Bortone SA. 1980. Abnormal expression of secondary sex characters in a population of mosquitofish, Gambusia affinis holbrooki: Evidence for environmentally-induced masculinization. Copeia 4: 676681.
  • 122
    Strussman CA, Patino R. 1995. Temperature manipulation of sex differentiation in fish. In Goetz F, Thomas P, eds, Proceedings, 5th International Symposium on the Reproductive Physiology of Fish—Fish Symposia 95. University of Texas Press, Austin, TX, USA, July 2–8, pp 153157.
  • 123
    MacLatchy DL, Van Der Kraak GJ. 1995. The phytoestrogen β-sitosterol alters the reproductive status of goldfish. Toxicol Appl Pharmacol 134: 305312.
  • 124
    Afonso LOB, Campbell PM, Iwama GK, Devlin RH, Donaldson EM. 1997. The effect of the aromatase inhibitor Fadrozole and two polynuclear aromatic hydrocarbons on sex steroid secretion by ovarian follicles of coho salmon. Gen Comp Endocrinol 106: 169174.
  • 125
    Thomas P. 1989. The effects of Aroclor 1254 and cadmium on reproductive endocrine function and ovarian growth on Atlantic croaker. Mar Environ Res 28: 499503.
  • 126
    Kahn I, Thomas P. 1996. Disruption of neuroendocrine function in Atlantic croaker exposed to Aroclor 1254. Mar Environ Res 42: 145149.
  • 127
    Bresch H. 1982. Investigations of the long-term action of xenobiotics on fish with special regard to reproduction. Ecotoxicol Environ Saf 6: 102112.
  • 128
    Holcombe GW, Benoit DA, Hammermeister DE, Leonard EN, Johnson RD. 1995. Acute and long-term effects of nine chemicals on the Japanese medaka (Oryzias latipes). Arch Environ Contam Toxicol 28: 287297.
  • 129
    BrookeLT, CallDJ, GeigerDL, NorthcottCE, eds. 1984. Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Vol. 1. Center for Lake Superior Studies, University of Wisconsin-Superior, Superior, WI, USA.
  • 130
    GeigerDL, NorthcottCE, CallDJ, BrookeLT, eds. 1985. Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Vol. 2. Center for Lake Superior Environmental Studies, University of Wisconsin-Superior, Superior, WI, USA.
  • 131
    GeigerDL, PoirierSH, BrookeLT, CallDJ, eds. 1986. Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Vol. 3. Center for Lake Superior Environmental Studies, University of Wisconsin-Superior, Superior, WI, USA.
  • 132
    GeigerDL, CallDJ, BrookeLT, eds. 1988. Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas)., Vol. 4. Center for Lake Superior Environmental Studies, University of Wisconsin-Superior, Superior, WI, USA.
  • 133
    GeigerDL, CallDJ, BrookeLT, eds. 1990. Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Vol. 5. Center for Lake Superior Environmental Studies, University of Wisconsin-Superior, Superior, WI, USA.
  • 134
    Driever W, Stemple D, Schier A, Solnica-Krezel L. 1994. Zebrafish: Genetic tools for monitoring vertebrate development. Trends Genet 10: 152158.
  • 135
    Shi M, Faustman EM. 1989. Development and characterization of a morphological scoring system for medaka (Oryzias latipes) embryo culture. Aquat Toxicol 15: 127140.
  • 136
    Thomann RV, Connolly JP. 1984. Model of PCB in the Lake Michigan lake trout food chain. Environ Sci Technol 18: 6571.
  • 137
    Oliver BG, Niimi AJ. 1985. Bioconcentration factors of some halogenated organics for rainbow trout and limitations in their use for prediction of environmental residues. Environ Sci Technol 19: 842848.
  • 138
    Lazier CB, MacKay ME. 1993. Vitellogenin gene expression in teleost fish. In HochachkaPW, MommsenTP, eds, Biochemistry and Molecular Biology of Fishes, Vol. 2. Elsevier, Amsterdam, The Netherlands, pp 391405.
  • 139
    Black JJ, Maccubbin AE, Schiffert M. 1985. A reliable, efficient, microinjection apparatus and methodology for the in vivo exposure of rainbow trout and salmon embryos to chemical carcinogens. J Natl Cancer Inst 75: 11231128.
  • 140
    Ren LA, Meldahl A, Lech JJ. 1996. Dimethylformamide (DMFA) and ethylene glycol (EG) are estrogenic in rainbow trout. Chem Biol Interact 102: 6367.
  • 141
    Gessner PK. 1974. The isobolagraphic method applied to drug interactions. In MorselliPL, GarattiniS, CohenSN, eds, Drug Interactions. Raven, New York, NY, USA, pp 349362.
  • 142
    Zabel EW, Walker MK, Hornung MW, Clayton MK, Peterson RE. 1995. Interactions of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners for producing rainbow trout early life stage mortality. Toxicol Appl Pharmacol 134: 304313.
  • 143
    Keith JA. 1966. Reproduction in a population of herring gulls (Larus argentatus) contaminated by DDT. J Appl Ecol 3: 5770.
  • 144
    Anderson DW, Hickey JJ. 1970. Oological data on egg and breeding characteristics of brown pelicans. Wilson Bull 82: 1428.
  • 145
    Cooke AS. 1973. Shell thinning in avian eggs by environmental pollutants. Environ Pollut 4: 85152.
  • 146
    Fry DM, Toone CK. 1981. DDT-induced feminization of gull embryos. Science 213: 922924.
  • 147
    Gilbertson M, Kubiak T, Ludwig J, Fox G. 1991. Great Lakes embryo mortality, edema and deformities syndrome (GLE-MEDS) in colonial fish-eating birds: Similarity to chick edema disease. J Toxicol Environ Health 33: 455520.
  • 148
    Romanoff AJ. 1960. The Avian Embryo. Macmillan, New York, NY, USA.
  • 149
    Boss WR, Witschi E. 1947. The permanent effects of early stilbestrol injections on the sex organs of the herring gull (Larus argentatus). J Exp Zool 105: 6177.
  • 150
    Adkins EK. 1975. Hormonal basis of sexual differentiation in the Japanese quail. J Comp Physiol 89: 6171.
  • 151
    Bulger RM, Muccitelli RM, Kupfer D. 1978. Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation. J Clin Pharmacol 27: 24172423.
  • 152
    Eroschenko VP. 1981. Estrogenic activity of the insecticide chlordecone in the reproductive tract of birds and mammals. J Toxicol Environ Health 8: 731742.
  • 153
    Kupfer D, Bulger WH. 1987. Metabolic activation of pesticides with proestrogenic activity. Fed Proc 46: 18641869.
  • 154
    Kubiak T, et al. 1989. Microcontaminants and reproductive impairment of the Forster's tern in Green Bay, Lake Michigan– 1983. Arch Environ Contam Toxicol 18: 706727.
  • 155
    Greenwood AW, Blythe JSS. 1938. Experimental modification of the accessory sexual apparatus in the hen. Q J Exp Physiol 28: 6169.
  • 156
    Organization for Economic Cooperation and Development. 1984. OECD guidelines for testing of chemicals. Guideline 206. Avian reproduction test. Paris, France.
  • 157
    Bennett RS, Ganio LM. 1991. Overview of methods for evaluating effects of pesticides on reproduction in birds. EPA 600/ 3–91–048. U.S. Environmental Protection Agency, Corvallis, OR.
  • 158
    Organization for Economic Cooperation and Development. 1996. Report of the SETAC/OECD workshop on avian toxicity testing. OECD/GD(96)166. Paris, France.
  • 159
    Bitman J, Cecil HC, Harris SJ, Fries GF. 1968. Estrogenic activity of o,p'-DDT in the mammalian uterus and avian oviduct. Science 162: 371372.
  • 160
    Cain JR, Lien RJ, Beasom SL. 1987. Phytoestrogen effects on reproductive performance of scaled quail. J Wildl Manage 51: 198201.
  • 161
    Johnson JO, Kariya T, Leavitt WW, Petrow V. 1980. Growth and lipemic activity of 19-oxo-androstenededione: A potential growth stimulant for poultry. Poult Sci 59: 390395.
  • 162
    Zarrow MX, Peters LE, Caldwell AL, Jr. 1960. Comparative potency of several progestogenic compounds in a battery of different biological tests. Ann NY Acad Sci 71: 532541.
  • 163
    Munson PL, Sheps MC. 1958. An improved procedure for the biological assay of androgens by direct application to the comb of baby chicks. Endocrinology 62: 173184.
  • 164
    Dorfman RI, Rooks WH II, Jones JB, Leman JD. 1966. Androgenic activity of highly purified 5-androstane and 5-androstane- 17-ol. J Med Chem 9: 930931.
  • 165
    Gawienowski AM, Stadnicki SS, Stacewicz-Sapuntzakis M. 1977. Androgenic properties of gibberellic acid in the chick comb bioassay. Experientia 33: 15441545.
  • 166
    Hennessey JV, Glass AR, Barns S, Vigersky RA. 1986. Comparative antiandrogenic potency of spironolactone and cimetidine: Assessment by the chicken cockscomb topical bioassay. Proc Soc Exp Biol Med 182: 443447.
  • 167
    Boris A, Stevenson RH. 1966. Further studies on a nonsteroidal anti-androgen. Endocrinology 78: 549555.
  • 168
    Perrin FMR, Stacey S, Burgess AMC, Mittwoch U. 1995. A quantitative investigation of gonadal feminization by diethylstilbestrol of genetically male embryos of the quail Coturnix coturnix japonica. J Reprod Fertil 103: 223226.
  • 169
    Nosek JA, Sullivan JR, Craven SR, Gendron-Fitzpatrick A, Peterson RE. 1993. Embryotoxicity of 2,3,7,8-tetrachlorodibenzo- p-dioxin in the ring-necked pheasant. Environ Toxicol Chem 12: 12151222.
  • 170
    Powell DC, et al. 1997. Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or an extract derived from field-collected cormorant eggs injected into double-crested cormorant (Phalacrocorax auritus) eggs. Environ Toxicol Chem 16: 14501455.
  • 171
    Robinson GA, Gibbins AMV. 1984. Induction of vitellogenesis in Japanese quail as a sensitive indicator of the estrogen-mimetic effect of a variety of environmental contaminants. Poult Sci 63: 15291536.
  • 172
    Hugla JL, Goffinet G, Kremers P, Dubois M, Lambert V, Stouvenakers N, Thome JP. 1996. Ultrastructural modifications in cultured fetal quail hepatocytes exposed to pesticides and PCBs. Ecotoxicol Environ Saf 34: 145155.
  • 173
    Kennedy SW, Lorenzen A, Jones SP, Hahn ME, Stegeman JJ. 1996. Cytochrome P4501A induction in avian hepatocyte cultures: A promising approach for predicting the sensitivity of avian species to toxic effects of halogenated aromatic hydrocarbons. Toxicol Appl Pharmacol 141: 214230.
  • 174
    Krust A, Green S, Argos P, Kumar V, Walter P, Bornert JM, Chambon P. 1986. The chicken oestrogen receptor sequence: Homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J 5: 891897.
  • 175
    Maxwell BL, McDonnell DP, Conneely OM, Schulz TZ, Greene GL, O'Malley BW. 1987. Structural organization and regulation of the chicken estrogen receptor. Mol Endocrinol 1: 2535.
  • 176
    Vilchis R, Chavez B, Perez-Palacios G. 1991. Steroid hormone binding in the Harderian gland of birds: Characteristics of the androgen, estrogen, and progestin receptors of Anas platyrhynchos and Gallus domesticus. Gen Comp Endocrinol 82: 425433.
  • 177
    Balthazart J, Foidart A, Wilson EM, Ball GF. 1992. Immunocytochemical localization of androgen receptors in the male songbird and quail brain. J Comp Neurol 317: 407420.
  • 178
    Gahr M, Guttinger HR, Kroodsma DE. 1993. Estrogen receptors in the avian brain: Survey reveals general distribution and forebrain areas unique to songbirds. J Comp Neurol 327: 112122.
  • 179
    Gahr M, Metzdorf R, Aschenbrenner S. 1996. The ontogeny of the canary HVC revealed by the expression of androgen and oestrogen receptors. Neuroreport 8: 311315.
  • 180
    Elbrecht A, Smith RG. 1992. Aromatase enzyme activity and sex determination in chickens. Science 255: 467470.
  • 181
    Abinawanto SK, Yoshida K, Saito N. 1996. Effects of aromatase inhibitor on sex differentiation and levels of P450(17-Alpha) and P450(AROM) messenger ribonucleic acid of gonads in chicken embryos. Gen Comp Endocrinol 102: 241246.
  • 182
    George FW, Wilson JD. 1982. Developmental pattern of increased aromatase activity in the Sebright bantam chicken. Endocrinology 110: 12031207.
  • 183
    Schlinger BA, Arnold AP. 1992. Plasma sex steroids and tissue aromatization in hatchling zebra finches: Implications for the sexual differentiation of singing behavior. Endocrinology 130: 289299.
  • 184
    Adkins-Regan E, Mansukhani V, Seiwert C, Thompson R. 1994. Sexual differentiation of brain and behavior in the zebra finch: Critical periods for effects of early estrogen treatment. J Neurobiol 25: 865877.
  • 185
    Woodward AR, Percival HF, Jennings ML, Moore CT. 1993. Low clutch viability of American alligators on Lake Apopka. Fla Sci 56: 5263.
  • 186
    Crews D, Wibbels T, Gutzke WHN. 1989. Action of sex steroid hormones on temperature-induced sex determination in the snapping turtle (Chelydra serpentine). Gen Comp Endocrinol 76: 159166.
  • 187
    Bergeron JM, Crews D, McLachlan JA. 1994. PCBs as environmental estrogens: Turtle sex determination as a biomarker of environmental contamination. Environ Health Perspect 102: 780781.
  • 188
    Blaustein AR, Wake DB. 1995. The puzzle of declining amphibian populations. Sci Am 272: 5263.
  • 189
    Pechman JHK, Wilbur HM. 1994. Putting declining amphibian populations in perspective: Natural fluctuations and human impacts. Herpetologica 50: 6584.
  • 190
    Ramsdell HS, Blandin DA, Schmechel TR. 1996. Developmental effects and biochemical markers of alkylphenol exposure in frog larvae. Proceedings, 17th Annual Meeting of the Society of Environmental Toxicology and Chemistry, Washington, DC, November 17–21, p 140.
  • 191
    Gutzke WHN, Bull JJ. 1986. Steroid hormones reverse sex in turtles. Gen Comp Endocrinol 64: 368372.
  • 192
    Rhen R, Lang JW. 1994. Temperature-dependent sex determination in the snapping turtle: Manipulation of the embryonic sex steroid environment. Gen Comp Endocrinol 96: 243254.
  • 193
    Crews D, Bergeron JM. 1994. Role of reductase and aromatase in sex determination in the red-eared slider (Trachemys scripta), a turtle with temperature-dependent sex determination. J Endocrinol 143: 279289.
  • 194
    Lance VA, Bogart MH. 1994. Studies on sex determination in the American alligator Alligator mississippiensis. J Exp Zool 270: 7985.
  • 195
    Villalpando I, Merchant-Larios H. 1990. Determination of the sensitive stages for gonadal sex reversal in Xenopus laevis tadpoles. Int J Dev Biol 34: 282285.
  • 196
    Bantle JA, et al. 1994. Initial interlaboratory validation study of FETAX: Phase I testing. J Appl Toxicol 14: 213223.
  • 197
    Bantle JA, et al. 1994. Initial interlaboratory validation study of FETAX: Phase II testing. Environ Toxicol Chem 13: 16291637.
  • 198
    Bantle JA. 1996. FETAX interlaboratory validation study: Phase III—Part 1 testing. J Appl Toxicol 16: 517528.
  • 199
    Bantle JA. 1993. FETAX—A developmental toxicity assay using frog embryos. In RandGM, ed, Fundamentals of Aquatic Toxicology, 2nd ed. Taylor and Francis, Washington, DC, pp 207230.
  • 200
    American Society for Testing and Materials. 1991. New standard guide for conducting the frog embryo teratogenesis assay—Xenopus (FETAX). E1439–91. In Annual Book of ASTM Standards, Vol 11.05. Philadelphia, PA, pp 821835.
  • 201
    Palmer B, Palmer SK. 1995. Vitellogenin induction by xenobiotic estrogens in the red-eared turtle and African clawed frog. Environ Health Perspect 103: 1925.
  • 202
    Gross TS, Guillette LJ. 1994. Pesticide induction of developmental abnormalities of the reproductive system of alligators (Alligator mississippiensis) and turtles (Trachemys scripta). In Estrogens in the Environment III: Global Health Implications. National Institute of Environmental Health Sciences, Washington, DC.
  • 203
    Ho SM, Fehrer S, Yu M, Liang LC, Press D. 1988. High-affinity binding of [3H]estradiol-17 beta by an estrogen receptor in the liver of the turtle. Gen Comp Endocrinol 70: 382394.
  • 204
    Giannoukos G, Callard IP. 1996. Radioligand and immunochemical studies of turtle oviduct progesterone and estrogen receptors: Correlations with hormone treatment and oviduct contractility. Gen Comp Endocrinol 101: 6375.
  • 205
    Young LJ, Godwin J, Grammar M, Gahr M, Crews D. 1995. Reptilian sex steroid receptors: Amplification, sequence and expression analysis. J Steroid Biochem Mol Biol 55: 262269.
  • 206
    Godwin J, Crews D. 1995. Sex differences in estrogen and progesterone receptor messenger ribonucleic acid regulation in the brain of little striped whiptail lizards. Neuroendocrinology 62: 293300.
  • 207
    Weiler IJ, Lew D, Shapiro DJ. 1987. The Xenopus laevis estrogen receptor: Sequence homology with human and avian receptors and identification of multiple estrogen receptor messenger ribonucleic acids. Mol Endocrinol 1: 355362.
  • 208
    Savouret JF, Bailly A, Misrahi M, Rauch C, Redeuilh G, Chauchereau A, Milgrom E. 1991. Characterization of the hormone responsive element involved in the regulation of the progesterone receptor gene. EMBO J 10: 18751883.
  • 209
    Tata JR, Baker BS, Machuca I, Rabelo EM, Yamauchi K. 1993. Autoinduction of nuclear receptor genes and its significance. J Steroid Biochem Mol Biol 46: 105119.
  • 210
    Perez J, Cohen MA, Kelley DB. 1996. Androgen receptor mRNA expression in Xenopus laevis CNS: Sexual dimorphism and regulation in laryngeal motor nucleus. J Neurobiol 30: 556568.
  • 211
    Sagata N. 1997. What does MOS do in oocytes and somatic cells. Bioessays 19: 1321.
  • 212
    Gebauer F, Richter JD. 1997. Synthesis and function of MOS: The control switch of vertebrate meiosis. Bioessays 19: 2328.
  • 213
    Riegel AT, Jordan VC, Bain RR, Schoenberg DR. 1986. Effects of antiestrogens on the induction of vitellogenin and its mRNA in Xenopus laevis. J Steroid Biochem 24: 11411149.
  • 214
    Bettin C, Oehlmann J, Stroben E. 1996. TBT-induced imposex in marine neogastropods is mediated by an increasing androgen level. Helgol Meeresunters 50: 299317.
  • 215
    Moore CG, Stevenson JM. 1991. The occurrence of intersexuality in harpacticoid copepods and its relationship with pollution. Mar Pollut Bull 22: 7274.
  • 216
    Ronis MJJ, AZ Mason. 1996. The metabolism of testosterone by the periwinkle (Littorina littorea) in vitro and in vivo: Effects of tributyltin. Mar Environ Res 42: 161166.
  • 217
    LeBlanc GA, Bain LJ. 1997. Chronic toxicity of environmental contaminants: Sentinels and biomarkers. Environ Health Perspect 105: 6580.
  • 218
    Zou E, Fingerman M. 1997. Synthetic estrogenic agents do not interfere with sex differentiation but do inhibit molting of the cladoceran Daphnia magna. Bull Environ Contam Toxicol 58: 596602.
  • 219
    LeBlanc GA. 1998. Steroid hormone-regulated processes in invertebrates and their susceptibility to environmental endocrine disruption. In GuilletteLJ, Jr., ed, Environmental Endocrine Disruptors: An Evolutionary Perspective. Taylor and Francis, London, UK (in press).
  • 220
    Baldwin WS, Leblanc GA. 1994. Identification of multiple steroid hydroxylases in Daphnia magna and their modulation by xenobiotics. Environ Toxicol Chem 13: 10131021.
  • 221
    Baldwin WS, Leblanc GA. 1994. In vivo biotransformation of testosterone by phase I and II detoxication enzymes and their modulation by 20-hydroxyecdysone in Daphnia magna. Aquat Toxicol 29: 103117.
  • 222
    Chang ES, O'Connor D. 1988. Crustacea: Molting. In LauferH, DownerGH, eds, Endocrinology of Selected Invertebrate Types. Alan R. Liss, New York, NY, USA, pp 259278.
  • 223
    Charniaux-Cotton H, Payen G. 1988. Crustacean reproduction. In LauferH, DownerGH, eds, Endocrinology of Selected Invertebrate Types. Alan R. Liss, New York, NY, USA, pp 279203.
  • 224
    Wigglesworth VB. 1970. Insect Hormones. W.H. Freeman, San Francisco, CA, USA.
  • 225
    Bowers WS. 1990. Prospects for the use of insect growth regulators in agriculture. In HoshiM, YamashitaO, eds, Advances in Invertebrate Reproduction 5. Elsevier, New York, NY, USA, pp 365382.
  • 226
    Benoit DA, Sibley PK, Juenenann JL, Ankley GT. 1997. Chironomus tentans life cycle test: Design and evaluation for use in assessing toxicity of contaminated sediments. Environ Toxicol Chem 16: 11651176.
  • 227
    Organization for Economic Cooperation and Development. 1992. OECD guidelines for testing of chemicals. Section 2: Guideline 202. Daphnia sp. acute immobilization test and reproduction test. Paris, France
  • 228
    Snell TW, Carmona MJ. 1995. Comparative toxicant sensitivity of sexual and asexual reproduction in the rotifer Brachionus calyciflorus. Environ Toxicol Chem 14: 415420.