Scale-up of analytical chromatography to the simulated moving bed separation of the enantiomers of the flavour norterpenoids α-ionone and α-damascone



The scale-up of the HPLC separation of the enantiomers of the flavour norterpenoid ketones α-ionone and α-damascone from analytical to preparative scale was achieved using the chromatographic simulated moving bed (SMB) technique. Commercial HPLC columns, with heptakis-(2,3,6-per-O-methyl)-β-cyclodextrin bound to silica gel as chiral stationary phase, were employed for the separation. High-purity enantiomers of both chiral compounds have been obtained with a rather satisfactory productivity. Copyright © 2002 John Wiley & Sons, Ltd.