Institute of Clinical Neurobiology, University of Würzburg, 97078 Würzburg, Germany
Special Issue Paper
GABAA receptor modulation by the volatile fractions of Sideritis species used as ‘Greek’ or ‘Turkish’ mountain tea†
Article first published online: 28 MAY 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Flavour and Fragrance Journal
Special Issue: Special Issue Part 1: 13th Weurman Flavour Research Symposium Zaragoza, Spain, 27th – 30th September 2011
Volume 27, Issue 4, pages 297–303, July 2012
How to Cite
Kessler, A., Villmann, C., Sahin-Nadeem, H., Pischetsrieder, M. and Buettner, A. (2012), GABAA receptor modulation by the volatile fractions of Sideritis species used as ‘Greek’ or ‘Turkish’ mountain tea. Flavour Fragr. J., 27: 297–303. doi: 10.1002/ffj.3099
This article is published in Flavour and Fragrance Journal as Part I of Special Issue: 13th Weurman Flavour Research Symposium, Zaragoza, Spain, 27th – 30th September 2011, edited by Vicente Ferreira (University of Zaragoza).
- Issue published online: 22 JUN 2012
- Article first published online: 28 MAY 2012
- Manuscript Accepted: 13 APR 2012
- Manuscript Revised: 20 MAR 2012
- Manuscript Received: 16 JAN 2012
- neurotropic modulation;
- GABAA receptor;
Sideritis spp. is a member of the Labiateae family, used in traditional folk medicine and as a calming tea preparation. Dichloromethane extracts of the aerial parts of four Sideritis species were prepared, and the volatile fractions were separated via solvent-assisted flavour evaporation distillation. In vitro electrophysiological techniques were used to investigate the physiological effects of these aroma extracts on ionotropic γ-aminobutyric acid receptors (GABAA) in comparison to extracts of Lavandula spp. (lavender) obtained by the same approach. The plant extracts of Sideritis spp. and Lavandula spp. increased the maximal current responses gated by the agonist GABA, both in whole cell patch clamp recordings as well as in two electrode voltage clamp assays. Thereby, the volatile fractions caused a dose-dependent enhancement of GABAergic currents. Differences in activity between the various species were probably due to variations in odorant composition, either on a qualitative or quantitative basis. Thus, the plant material contains volatile organic compounds, which are able to modulate a GABA-mediated response and thereby possibly contribute to a sedative effect in vivo. Copyright © 2012 John Wiley & Sons, Ltd.