This article is published in Flavour and Fragrance Journal as Part II of Special Issue: 13th Weurman Flavour Research Symposium, Zaragoza, Spain, 27th–30th September 2011, edited by Vicente Ferreira (University of Zaragoza).
Special Issue Paper
Interaction between odorants and proteins involved in the perception of smell: the case of odorant-binding proteins probed by molecular modelling and biophysical data†
Article first published online: 5 OCT 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Flavour and Fragrance Journal
Special Issue: Special Issue Part II 13th Weurman Flavour Research Symposium Zaragoza, Spain, 27th – 30th September 2011
Volume 27, Issue 6, pages 445–453, November 2012
How to Cite
Golebiowski, J., Topin, J., Charlier, L. and Briand, L. (2012), Interaction between odorants and proteins involved in the perception of smell: the case of odorant-binding proteins probed by molecular modelling and biophysical data. Flavour Fragr. J., 27: 445–453. doi: 10.1002/ffj.3121
- Issue published online: 16 OCT 2012
- Article first published online: 5 OCT 2012
- Manuscript Accepted: 22 JUL 2012
- Manuscript Revised: 20 JUL 2012
- Manuscript Received: 3 JAN 2012
A joint approach that combines molecular modelling and fluorescence spectroscopy is used to study the affinity of an odorant binding protein towards various odorant molecules. We focus on the capability of molecular modelling to rank odorants according to their affinity with this protein, which is involved in the sense of smell. Although ligand-based approaches are unable to propose an accurate model attending to the strength of the bond with the odorant-binding protein, receptor-based structures considering either static or dynamic structure of the protein perform equally to discriminate between good, medium and low affinity odorants. Such approaches will be useful for further rational design of either odorants or bio-inspired sensors. Copyright © 2012 John Wiley & Sons, Ltd.