Evaluation of the anti-inflammatory and antinociceptive effects of myrtenol, a plant-derived monoterpene alcohol, in mice (pages 184–192)
Renan O. Silva, Mirian S. Salvadori, Francisca Beatriz M. Sousa, Maisa S. Santos, Nathalia S. Carvalho, Damião P. Sousa, Bruno S. Gomes, Francisco A. Oliveira, André Luiz R. Barbosa, Rivelilson M. Freitas, Reinaldo Nóbrega de Almeida and Jand-Venes R. Medeiros
Article first published online: 19 FEB 2014 | DOI: 10.1002/ffj.3195
In the present study, we demonstrated that (−)-myrtenol, a plant-derived monoterpene alcohol, exhibits a pronounced anti-inflammatory and antinociceptive effect in different animal models. Our data suggested that myrtenol reduces the inflammatory response and nociception in mice due to the inhibition of the release of inflammatory mediators, cell migration and also to the signalling pathway of receptors involved in the transmission of pain.