Research Article

Application of Chimera grid to modelling cell motion and aggregation in a narrow tube

  1. B. Chung1,
  2. P. C. Johnson2,
  3. A. S. Popel1,*

Article first published online: 19 JUN 2006

DOI: 10.1002/fld.1251

Issue

International Journal for Numerical Methods in Fluids

International Journal for Numerical Methods in Fluids

Volume 53, Issue 1, pages 105–128, 10 January 2007

Additional Information

How to Cite

Chung, B., Johnson, P. C. and Popel, A. S. (2007), Application of Chimera grid to modelling cell motion and aggregation in a narrow tube. Int. J. Numer. Meth. Fluids, 53: 105–128. doi: 10.1002/fld.1251

Author Information

  1. 1

    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, U.S.A.

  2. 2

    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, U.S.A.

*Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, U.S.A.

Publication History

  1. Issue published online: 28 NOV 2006
  2. Article first published online: 19 JUN 2006
  3. Manuscript Accepted: 11 APR 2006
  4. Manuscript Revised: 7 APR 2006
  5. Manuscript Received: 9 JAN 2006

Funded by

  • NIH. Grant Number: HL 52684

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (564K)

Keywords:

  • Chimera grid;
  • red blood cell;
  • RBC aggregation;
  • depletion interaction energy

Abstract

A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three-dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network. Copyright © 2006 John Wiley & Sons, Ltd.

Get PDF (564K)