Numerical simulation of orbitally shaken viscous fluids with free surface (pages 294–315)
Marco Discacciati, David Hacker, Alfio Quarteroni, Samuel Quinodoz, Stéphanie Tissot and Florian M. Wurm
Article first published online: 14 FEB 2012 | DOI: 10.1002/fld.3658
Orbitally shaken bioreactors are an emerging alternative to stirred-tank bioreactors for large-scale mammalian cell culture, but their fluid dynamics is still not well-defined. Among the theoretical and practical issues that remain to be resolved, the characterization of the liquid free surface during orbital shaking remains a major challenge because it is an essential aspect of gas transfer and mixing in these reactors.