In six young hospitalized men the effect of a high dietary sugar intake (mean sugar content was 52.5 kcal% on a 2850 kcal-diet) on body-weight, body fat ratio (calculated from body density) and some metabolic and regulatory indicators was investigated.
Although there was a great individual variability of values, a statistically significant increase of the body fat was recorded on the 22nd day on the high-sugar diet (from ± 1.0 to 2.1%); a statistically significant increase of cholesterol, triglyceride and esterified fatty acid levels was recorded on the 10th day, phospholipids did not change.
Two weeks after discontinuation of this diet the investigated indicators practically returned to normal levels.
After 24 days on the diet a slight increase of the insulinaemia on fasting was recorded and in four subjects higher maximum values of insulinaemia were obtained after half the amount of glucose. An increased catecholamine excretion was found: of noradrenaline (significant on the 3rd and 10th day on the diet) and of vanilylmandelic acid (significant on the 3rd and 17th day on the diet).