Protective effect of resveratrol against pressure overload-induced heart failure

Authors

  • Prakash K. Gupta,

    1. Department of Cell Biology & Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina
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  • Donald J. DiPette,

    1. Department of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina
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  • Scott C. Supowit

    Corresponding author
    1. Department of Cell Biology & Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina
    • Correspondence

      Scott C. Supowit, Department of Cell Biology & Anatomy, University of South Carolina School of Medicine, 6439 Garners Ferry Rd, Columbia, SC 29209. Tel: 803-216-3822; Fax: 803-216-3847; E-mail: scott.supowit@uscmed.sc.edu

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Abstract

Transverse aortic constriction (TAC)-induced pressure overload (PO) causes adverse cardiac remodeling and dysfunction that progresses to heart failure (HF). The purpose of this study was to determine whether the potent antioxidant, resveratrol, significantly attenuates PO-induced HF in wild-type mice. Male C57BL6 mice were subjected to either sham or TAC surgery. One group of TAC mice was given daily resveratrol treatment. Echocardiographic, biometric, and immunohistological analyses were performed on the three groups of mice. All echocardiographic parameters demonstrated significantly greater adverse cardiac remodeling and dysfunction in the TAC compared to the sham mice. Increases in the ratios of heart weight (HW)/body weight (BW) and lung weight (LW)/BW and a sharp decline in the percentage of ejection fraction and fractional shortening were found in TAC relative to sham mice. Likewise, the TAC protocol increased markers of oxidative stress, cardiac hypertrophy, inflammation, fibrosis, hypoxia, and apoptosis. These pathological changes were significantly attenuated by resveratrol treatment. Resveratrol treatment significantly attenuates the adverse cardiac remodeling and dysfunction produced by the TAC protocol in C57/BL6 mice and this activity is mediated, at least in part, by the inhibition of oxidative stress and inflammation indicating a therapeutic potential of resveratrol in HF.

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