Thomas Mercher and Florence Nguyen Khac are recipients of fellowships from the Ministère de l'education Nationale and the Académie Nationale de Médecine, respectively.
Recurrence of OTT–MAL fusion in t(1;22) of infant AML-M7†
Article first published online: 8 NOV 2001
Copyright © 2002 Wiley-Liss, Inc.
Genes, Chromosomes and Cancer
Volume 33, Issue 1, pages 22–28, January 2002
How to Cite
Mercher, T., Busson-Le Coniat, M., Khac, F. N., Ballerini, P., Mauchauffé, M., Bui, H., Pellegrino, B., Radford, I., Valensi, F., Mugneret, F., Dastugue, N., Bernard, O. A. and Berger, R. (2002), Recurrence of OTT–MAL fusion in t(1;22) of infant AML-M7. Genes Chromosom. Cancer, 33: 22–28. doi: 10.1002/gcc.1208
- Issue published online: 6 DEC 2001
- Article first published online: 8 NOV 2001
- Manuscript Accepted: 29 MAY 2001
- Manuscript Received: 27 MAR 2001
- Ligue Nationale Contre le Cancer
Translocation t(1;22)(p13;q13) is associated with a peculiar subtype of acute megakaryocytic leukemia (M7) occurring in infants. We have recently characterized a fusion gene, OTT–MAL, resulting from this translocation. We now report three additional cases and show that this gene fusion is present in all five t(1;22) cases studied to date. Nucleotide sequence analysis of two translocation breakpoints suggests a nonhomologous end joining mechanism in the genesis of this translocation and reveals a noncanonical topoisomerase II-like consensus sequence within the OTT gene. FISH and PCR techniques described in this work are useful for identifying t(1;22) associated with M7.