B.P. and P.D.P. contributed equally to this article.
PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements†
Version of Record online: 7 JUN 2005
Copyright © 2005 Wiley-Liss, Inc.
Genes, Chromosomes and Cancer
Volume 44, Issue 2, pages 218–223, October 2005
How to Cite
Poppe, B., De Paepe, P., Michaux, L., Dastugue, N., Bastard, C., Herens, C., Moreau, E., Cavazzini, F., Yigit, N., Van Limbergen, H., De Paepe, A., Praet, M., De Wolf-Peeters, C., Wlodarska, I. and Speleman, F. (2005), PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements. Genes Chromosom. Cancer, 44: 218–223. doi: 10.1002/gcc.20214
This text presents research results of the Belgian program of Interuniversity Poles of Attraction initiated by the Belgian State, Prime Minister's Office, Science Policy Programming. The scientific responsibility is assumed by the authors.
- Issue online: 2 AUG 2005
- Version of Record online: 7 JUN 2005
- Manuscript Accepted: 31 MAR 2005
- Manuscript Received: 18 NOV 2004
- Fund for Scientific Research of Flanders (FWO—Vlaanderen). Grant Number: G.0310.01
- Salus Sanguinis Foundation
We present an extensive characterization of 10 B-cell lymphomas with a t(9;14)(p13;q32). The presence of the PAX5/IGH gene rearrangement was demonstrated by fluorescence in situ hybridization (FISH) using a validated probe set, whereas complex karyotypic changes were reassessed by multiplex-FISH (M-FISH). Pathologic and clinical review revealed the presence of this rearrangement in 4 histiocyte-rich, T-cell-rich B-cell lymphomas (HRTR-BCLs) and 2 posttransplantation diffuse large B-cell lymphomas (PTLD-DLBCLs). In contrast to initial observations describing this translocation in lymphoplasmacytic lymphoma (LPL) and LPL-derived large B-cell lymphoma, our data showed a wide morphologic and clinical spectrum associated with the PAX5/IGH rearrangement, pointing to an association between this aberration and a subset of de novo DLBCLs presenting with advanced disease and adverse prognosis. In addition, the recurrent incidence of this rearrangement in both HRTR-BCL (4 cases) and PTLD-DLBCL (2 cases) was previously unrecognized and is intriguing. © 2005 Wiley-Liss, Inc.