t(3;14)(p14;q32) Results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma
Article first published online: 26 OCT 2005
Copyright © 2005 Wiley-Liss, Inc.
Genes, Chromosomes and Cancer
Volume 45, Issue 2, pages 164–168, February 2006
How to Cite
Fenton, J. A. L., Schuuring, E., Barrans, S. L., Banham, A. H., Rollinson, S. J., Morgan, G. J., Jack, A. S., van Krieken, J. Han. J. M. and Kluin, P. M. (2006), t(3;14)(p14;q32) Results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma. Genes Chromosom. Cancer, 45: 164–168. doi: 10.1002/gcc.20278
- Issue published online: 30 NOV 2005
- Article first published online: 26 OCT 2005
- Manuscript Accepted: 16 SEP 2005
- Manuscript Received: 9 FEB 2005
- Leukaemia Research Fund (UK)
Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers. © 2005 Wiley-Liss, Inc.