A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: An integrated genomics approach reveals a wide gene dosage effect
Version of Record online: 24 APR 2009
Copyright © 2009 Wiley-Liss, Inc.
Genes, Chromosomes and Cancer
Volume 48, Issue 7, pages 603–614, July 2009
How to Cite
Agnelli, L., Mosca, L., Fabris, S., Lionetti, M., Andronache, A., Kwee, I., Todoerti, K., Verdelli, D., Battaglia, C., Bertoni, F., Deliliers, G. L. and Neri, A. (2009), A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: An integrated genomics approach reveals a wide gene dosage effect. Genes Chromosom. Cancer, 48: 603–614. doi: 10.1002/gcc.20668
- Issue online: 6 MAY 2009
- Version of Record online: 24 APR 2009
- Manuscript Accepted: 31 MAR 2009
- Manuscript Received: 19 JAN 2009
- Associazione Italiana Ricerca sul Cancro
- Ministero Italiano della Salute; Associazione Italiana contro le Leucemie (AIL) di Milano
- Cantone Ticino “Ticino in rete”
- Fondazione per la Ricerca e la Cura dei Linfomi (Lugano, Switzerland)
- Fondazione Italiana Ricerca sul Cancro
Additional Supporting Information may be found in the online version of this article.
|GCC_20668_sm_SuppTable1.doc||204K||Table S1. Higher frequencies for gains and losses in 45MM dataset|
|GCC_20668_sm_SuppTable3.doc||219K||Table S3. List of the 144 genes at a q-value<0.01 whose expression levels correlate with relative copy number alteration|
|GCC_20668_sm_SuppTable4.doc||102K||Table S4. List of the 68 genes at a q-value<0.05 whose downregulation correlates with the occurrence of loss of heterozygosity|
|GCC_20668_sm_SuppFig6.doc||129K||Figure S6. Hierarchical clustering (Euclidean distance and Ward linkage metrics) of the 41 MM and 4 PCL samples based on conventional CN calculation procedure (FBN not applied) Vertical axis: primary tumors. Red boxes indicated the unrecognized near-tetraploid samples. Horizontal axis: absolute position. Heatmap of inferred CNs based on MCN: loss: green; normal copy-number: grey; gain: dark-red; amplification: light-red.|
|GCC_20668_sm_SuppFig7.doc||113K||Figure S7. Boxplot representation of the 68 genes which significantly correlated with the occurrence of LOH in the 40 MM samples dataset. The gene expression values are grouped according to the presence (LOH) or absence (w/o LOH) of LOH as assessed by Human Mapping arrays (horizontal axis). Vertical axis show absolute linear expression signal.|
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