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Review Article
High hyperdiploid childhood acute lymphoblastic leukemia
Article first published online: 4 MAY 2009
DOI: 10.1002/gcc.20671
Copyright © 2009 Wiley-Liss, Inc.
Additional Information
How to Cite
Paulsson, K. and Johansson, B. (2009), High hyperdiploid childhood acute lymphoblastic leukemia. Genes, Chromosomes and Cancer, 48: 637–660. doi: 10.1002/gcc.20671
Publication History
- Issue published online: 8 JUN 2009
- Article first published online: 4 MAY 2009
- Manuscript Accepted: 31 MAR 2009
- Manuscript Received: 4 MAR 2009
Funded by
- Swedish Childhood Cancer Foundation
- Swedish Cancer Society
- Swedish Research Council
- Abstract
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- Cited By
Abstract
High hyperdiploidy (51–67 chromosomes) is the most common cytogenetic abnormality pattern in childhood B-cell precursor acute lymphoblastic leukemia (ALL), occurring in 25–30% of such cases. High hyperdiploid ALL is characterized cytogenetically by a nonrandom gain of chromosomes X, 4, 6, 10, 14, 17, 18, and 21 and clinically by a favorable prognosis. Despite the high frequency of this karyotypic subgroup, many questions remain regarding the epidemiology, etiology, presence of other genetic changes, the time and cell of origin, and the formation and pathogenetic consequences of high hyperdiploidy. However, during the last few years, several studies have addressed some of these important issues, and these, as well as previous reports on high hyperdiploid childhood ALL, are reviewed herein. © 2009 Wiley-Liss, Inc.