Research Article

Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: Rare T-cell receptor gene rearrangements are associated with poor outcome

  1. Kristina Karrman1,*,
  2. Erik Forestier2,
  3. Mats Heyman3,
  4. Mette K. Andersen4,
  5. Kirsi Autio5,
  6. Elisabeth Blennow6,
  7. Georg Borgström5,
  8. Hans Ehrencrona7,
  9. Irina Golovleva8,
  10. Sverre Heim9,10,
  11. Kristiina Heinonen11,
  12. Randi Hovland12,
  13. Johann H. Johannsson13,
  14. Gitte Kerndrup14,
  15. Ann Nordgren6,
  16. Lars Palmqvist15,
  17. Bertil Johansson1

Article first published online: 15 JUN 2009

DOI: 10.1002/gcc.20684

Issue

Genes, Chromosomes and Cancer

Genes, Chromosomes and Cancer

Volume 48, Issue 9, pages 795–805, September 2009

Additional Information

How to Cite

Karrman, K., Forestier, E., Heyman, M., Andersen, M. K., Autio, K., Blennow, E., Borgström, G., Ehrencrona, H., Golovleva, I., Heim, S., Heinonen, K., Hovland, R., Johannsson, J. H., Kerndrup, G., Nordgren, A., Palmqvist, L. and Johansson, B. (2009), Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: Rare T-cell receptor gene rearrangements are associated with poor outcome. Genes Chromosom. Cancer, 48: 795–805. doi: 10.1002/gcc.20684

Author Information

  1. 1

    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden

  2. 2

    Department of Clinical Sciences, Pediatrics, University of Umeå, Umeå, Sweden

  3. 3

    Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden

  4. 4

    Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark

  5. 5

    Department of Pathology and Clinical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland

  6. 6

    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

  7. 7

    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden

  8. 8

    Department of Medical Biosciences, Medical and Clinical Genetics, University of Umeå, Umeå, Sweden

  9. 9

    Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway

  10. 10

    Faculty of Medicine, University of Oslo, Oslo, Norway

  11. 11

    Genetic Laboratory, ISLAB, Kuopio, Finland

  12. 12

    Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, Helse-Bergen HF, Norway

  13. 13

    Department of Clinical Genetics and Cytogenetics, University Hospital, Reykjavik, Iceland

  14. 14

    Department of Pathology, Odense University Hospital, Odense, Denmark

  15. 15

    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg, Sweden

*Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden

Publication History

  1. Issue published online: 6 JUL 2009
  2. Article first published online: 15 JUN 2009
  3. Manuscript Accepted: 19 MAY 2009
  4. Manuscript Received: 16 APR 2009

Funded by

  • Swedish Childhood Cancer Foundation
  • Swedish Cancer Society
  • Swedish Research Council

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