Research Article

Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

  1. Xiang Jiao1,
  2. Laura D. Wood2,
  3. Monica Lindman1,
  4. Sian Jones2,
  5. Phillip Buckhaults3,
  6. Kornelia Polyak4,5,6,
  7. Saraswati Sukumar7,
  8. Hannah Carter8,
  9. Dewey Kim8,
  10. Rachel Karchin8,
  11. Tobias Sjöblom1,*

Article first published online: 3 FEB 2012

DOI: 10.1002/gcc.21935

Issue

Genes, Chromosomes and Cancer

Genes, Chromosomes and Cancer

Volume 51, Issue 5, pages 480–489, May 2012

Additional Information

How to Cite

Jiao, X., Wood, L. D., Lindman, M., Jones, S., Buckhaults, P., Polyak, K., Sukumar, S., Carter, H., Kim, D., Karchin, R. and Sjöblom, T. (2012), Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers. Genes Chromosom. Cancer, 51: 480–489. doi: 10.1002/gcc.21935

Author Information

  1. 1

    Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

  2. 2

    The Ludwig Center for Cancer Genetics and Therapeutics, The Howard Hughes Medical Institute, Sidney Kimmel Cancer Center, Baltimore, MD

  3. 3

    Department of Pathology, Microbiology and Immunology, University of South Carolina, Columbia, SC

  4. 4

    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

  5. 5

    Department of Medicine, Brigham and Women's Hospital, Boston, MA

  6. 6

    Department of Medicine, Harvard Medical School, Boston, MA

  7. 7

    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD

  8. 8

    Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD

*Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden

Publication History

  1. Issue published online: 6 MAR 2012
  2. Article first published online: 3 FEB 2012
  3. Manuscript Revised: 19 DEC 2011
  4. Manuscript Accepted: 8 DEC 2011
  5. Manuscript Received: 4 OCT 2010

Funded by

  • National Institutes of Health. Grant Number: CA43460, CA573445, CA62924, CA121113
  • Swedish Cancer Foundation, D.K. Ludwig Fund for Cancer Research

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (967K)

Abstract

Exome sequencing of human breast cancers has revealed a substantial number of candidate cancer genes with recurring but infrequent somatic mutations. To determine more accurately their mutation prevalence, we performed a mutation analysis of 36 novel candidate cancer genes in 96 human breast cancers. Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF-KB, and PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved. © 2012 Wiley Periodicals, Inc.

View Full Article with Supporting Information (HTML) Get PDF (967K)