Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers
Article first published online: 3 FEB 2012
Copyright © 2012 Wiley Periodicals, Inc.
Genes, Chromosomes and Cancer
Volume 51, Issue 5, pages 480–489, May 2012
How to Cite
Jiao, X., Wood, L. D., Lindman, M., Jones, S., Buckhaults, P., Polyak, K., Sukumar, S., Carter, H., Kim, D., Karchin, R. and Sjöblom, T. (2012), Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers. Genes Chromosom. Cancer, 51: 480–489. doi: 10.1002/gcc.21935
- Issue published online: 6 MAR 2012
- Article first published online: 3 FEB 2012
- Manuscript Revised: 19 DEC 2011
- Manuscript Accepted: 8 DEC 2011
- Manuscript Received: 4 OCT 2010
- National Institutes of Health. Grant Number: CA43460, CA573445, CA62924, CA121113
- Swedish Cancer Foundation, D.K. Ludwig Fund for Cancer Research
Exome sequencing of human breast cancers has revealed a substantial number of candidate cancer genes with recurring but infrequent somatic mutations. To determine more accurately their mutation prevalence, we performed a mutation analysis of 36 novel candidate cancer genes in 96 human breast cancers. Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF-KB, and PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved. © 2012 Wiley Periodicals, Inc.