These authors contributed equally to this work.
Genetic score of multiple risk-associated single nucleotide polymorphisms is a marker for genetic susceptibility to bladder cancer
Version of Record online: 24 OCT 2013
Copyright © 2013 Wiley Periodicals, Inc.
Genes, Chromosomes and Cancer
Volume 53, Issue 1, pages 98–105, January 2014
How to Cite
Wang, P., Ye, D., Guo, J., Liu, F., Jiang, H., Gong, J., Gu, C., Shao, Q., Sun, J., Zheng, S. L., Yu, H., Lin, X., Xia, G., Fang, Z., Zhu, Y., Ding, Q. and Xu, J. (2014), Genetic score of multiple risk-associated single nucleotide polymorphisms is a marker for genetic susceptibility to bladder cancer. Genes Chromosom. Cancer, 53: 98–105. doi: 10.1002/gcc.22121
Supported by: Intramural grants, Fudan University “Thousand Talents Program”; Huashan Hospital.
- Issue online: 18 NOV 2013
- Version of Record online: 24 OCT 2013
- Manuscript Accepted: 26 SEP 2013
- Manuscript Received: 5 FEB 2013
Genome-wide association studies have identified 13 single nucleotide polymorphisms (SNPs) that are associated with bladder cancer; three of these SNPs were validated in the Chinese population. This study assessed the performance of these three SNPs, in combination, to predict genetic susceptibility to bladder cancer in Chinese. Three previously established bladder cancer risk-associated SNPs (rs798766 in TACC3, rs9642880 in MYC, and rs2294008 in PSCA) were genotyped in 1,210 bladder cancer patients and 1,008 control subjects in Shanghai, China. A genetic score was calculated for each subject based on these three SNPs. Each of these three SNPs was significantly associated with bladder cancer risk in this independent study population, P < 0.05. The genetic score based on these three SNPs was significantly higher in cases than controls, with a mean of 1.05 and 0.99, respectively, P = 1.03E-05. Compared with subjects with a genetic score <= 1.00, subjects with an elevated genetic score (>1.00) had a significantly increased risk for bladder cancer after adjusting for age, gender, and smoking status, OR = 1.58, 95% Confidence Interval (CI) = 1.21 − 2.06, P = 0.0007. When tested separately for lower (Ta) or higher (Tis, T1-T4) tumor stage, the association was significantly stronger for lower (OR = 2.24, 95% CI = 1.66 − 3.01, P = 1.02E-07) than higher tumor stage (OR = 1.33, 95% CI = 1.00 − 1.78, P = 0.05), P = 0.001. In conclusion, A combination of three previously implicated bladder cancer risk-associated SNPs is a significant predictor of genetic susceptibility to bladder cancer in Chinese. © 2013 Wiley Periodicals, Inc.