Cytogenetic findings in six posterior uveal melanomas: Involvement of chromosomes 3, 6, and 8

Authors

  • Dr. Karen Sisley,

    Corresponding author
    1. Section of Tumour Biology and Immunology, Department of Experimental and Clinical Microbiology, Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, and Centre for Human Genetics, Langhill, Sheffield, United Kingdom
    • Section of Tumour Biology and Immunology, Department of Experimental and Clinical Microbiology, Royal Hallamshire Hospital, Sheffield, UK
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  • Ian G. Rennie,

    1. Section of Tumour Biology and Immunology, Department of Experimental and Clinical Microbiology, Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, and Centre for Human Genetics, Langhill, Sheffield, United Kingdom
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  • David W. Cottam,

    1. Section of Tumour Biology and Immunology, Department of Experimental and Clinical Microbiology, Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, and Centre for Human Genetics, Langhill, Sheffield, United Kingdom
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  • Anthony M. Potter,

    1. Section of Tumour Biology and Immunology, Department of Experimental and Clinical Microbiology, Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, and Centre for Human Genetics, Langhill, Sheffield, United Kingdom
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  • Christopher W. Potter,

    1. Section of Tumour Biology and Immunology, Department of Experimental and Clinical Microbiology, Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, and Centre for Human Genetics, Langhill, Sheffield, United Kingdom
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  • Robert C. Rees

    1. Section of Tumour Biology and Immunology, Department of Experimental and Clinical Microbiology, Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, and Centre for Human Genetics, Langhill, Sheffield, United Kingdom
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Abstract

Six posterior uveal melanomas were karyotyped after short-term culture. One had a normal chromosome complement; the remaining five had limited chromosome changes. Involvement of chromosomes 1 and 6 was noted in two and four cases, respectively, and three ciliary body tumours demonstrated both monosomy 3 and i(8q).

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