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Abstract

Translocation t(9;22)(q22-31;q 1 1-12) is associated with the myxoid variant of chondrosarcorma We present here a report of a patient with a dedifferentiated grade IV chondrosarcorna, which originated from the iliac bone and contained areas of grade I chondrosarcoma There was no evidence of myxoid differentiation. The tumor had the karyotype 46,X,-X,t(9;22)(q34;q 1 1 -12). + mar[5]/52-61,x?,2-3dmin,inc[9]/46,XX[2]. It is possible that the different breakpoints in the t(9;22) may reflect different histopathologic subgroups of chondrosarcoma. Genes Chrom Cancer 9:136-140 (1994). © 1994 Wiley-Liss, Inc.