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Morpholino-induced knockdown of Fgf8 efficiently phenocopies the acerebellar (ACE) phenotype

  1. Isato Araki,
  2. Michael Brand*

Article first published online: 23 JUL 2001

DOI: 10.1002/gene.1054

Issue

genesis

genesis

Volume 30, Issue 3, pages 157–159, July 2001

Additional Information

How to Cite

Araki, I. and Brand, M. (2001), Morpholino-induced knockdown of Fgf8 efficiently phenocopies the acerebellar (ACE) phenotype. Genesis, 30: 157–159. doi: 10.1002/gene.1054

Author Information

  1. Max-Planck-Institute for Molecular Cell Biology and Genetics, Dresden, Germany

*Max-Planck-Institute for Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D-01307 Dresden, Germany

Publication History

  1. Issue published online: 23 JUL 2001
  2. Article first published online: 23 JUL 2001
  3. Manuscript Accepted: 18 JUN 2001
  4. Manuscript Received: 1 JUN 2001

Funded by

  • Alexander von Humboldt Stiftung
  • Deutsche Forschungsgemeinschaft
  • EU Biotech Program
  • Max-Planck Society

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LITERATURE CITED

  • Brand M, Heisenberg C-P, Jiang Y-J, Beuchle D, Lun K, van Eeden FJM, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane DA, Kelsh RN, Mullins MC, Odenthal J, Nüsslein-Volhard C. 1996. Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development 123: 179–190.
  • Lun K, Brand M. 1998. A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary. Development 125: 3049–3062.
  • Picker A, Brennan C, Reifers F, Clarke JD, Holder N, Brand M. 1999. Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection. Development 126: 2967–2978.
  • Raible F, Brand M. 2001. Tight transcriptional control of the ETS domain factors Erm and Pea3 by FGF signaling during early zebrafish nervous system development. Mech Dev (in press).
  • Reifers F, Böhli H, Walsh EC, Crossley PH, Stainier DYR, Brand M. 1998. Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. Development 125: 2381–2395.
  • Reifers F, Walsh EC, Léger S, Stainier DYR, Brand M. 2000a. Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar). Development 127: 225–235.
  • Reifers F, Adams J, Mason IJ, Schulte-Merker S, Brand M. 2000b. Overlapping and distinct functions provided by Fgf17, a new zebrafish member of the Fgf8/17/18 subgroup of Fgfs. Mech Dev 99: 39–49.
  • Shanmugalingam S, Houart C, Picker A, Reifers F, Macdonald R, Barth A, Griffin K, Brand M, Wilson SW. 2000. Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon. Development 127: 2549–2561.
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