Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis
Article first published online: 8 DEC 2005
Copyright © 2005 Wiley-Liss, Inc.
Volume 43, Issue 4, pages 196–204, December 2005
How to Cite
Chen, J., Kang, L. and Zhang, N. (2005), Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis. Genesis, 43: 196–204. doi: 10.1002/gene.20171
- Issue published online: 8 DEC 2005
- Article first published online: 8 DEC 2005
- Manuscript Accepted: 16 OCT 2005
- Manuscript Received: 29 AUG 2005
- March of Dimes Birth Defect Foundation. Grant Number: 1-FY2001-287
- Notch signal;
- 3′ untranslated region (3′-UTR)
Recent studies show that the cyclic expression of Lfng in the presomitic mesoderm (PSM) is controlled at the transcription level by Notch signal through the CBF1 binding site for activation and periodic repression on the Lfng promoter. Here we provide genetic evidence that the oscillatory expression is controlled by a negative feedback mechanism. We also show that Hes7, another cyclically expressed protein, can bind to the N-boxes on both Lfng and its own promoters and repress their activity. In addition, we demonstrate that the 3′ untranslated region (3′-UTR) is important for rapid degradation of Lfng mRNA. genesis 43:196–204, 2005. © 2005 Wiley-Liss, Inc.