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Keywords:

  • autoimmunity;
  • islet cell antibodies (ICA);
  • insulin autoantibodies (IAA);
  • insulin-dependent diabetes mellitus (IDDM);
  • pathogenesis of IDDM

Abstract

Antibodies to pancreatic islet cells and insulin were studied in the Genetic Analysis Workshop 5 (GAW5) families, as indicators of an autoimmune component of pathogenesis. The rationale for these studies is summarized briefly, and references to the laboratory methods used are provided.