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Original Article
Testing genetic models for IDDM by the MASC method
Article first published online: 3 JUN 2005
DOI: 10.1002/gepi.1370060112
Copyright © 1989 Wiley-Liss, Inc., A Wiley Company
Issue
1098-2272/asset/cover.gif?v=1&s=07484ac07e8bc9f07288a868034f014a9e749a16 "Genetic Epidemiology")
Genetic Epidemiology
Special Issue: Genetic Analysis of Complex trait: Insulin-Department Diabetes Mellitus and Affective Disorders
Volume 6, Issue 1, pages 59–64, 1989
Additional Information
How to Cite
Clerget-Darpoux, F. and Babron, M.-C. (1989), Testing genetic models for IDDM by the MASC method. Genet. Epidemiol., 6: 59–64. doi: 10.1002/gepi.1370060112
Publication History
- Issue published online: 3 JUN 2005
- Article first published online: 3 JUN 2005
- Abstract
- References
- Cited By
Keywords:
- genetic models;
- complementation;
- familial aggregation;
- differential risk;
- HLA antigens
Abstract
The MASC method has been applied to the GAW5 data. The method uses the simultaneous information on association and segregation of the HLA marker with the disease and the segregation of the HLA marker in affected families. It also takes into account the differential risk for parents of a patient, as well as the different HLA haplotype sharing, according to the HLA genotype of the patient. The goodness of fit of several genetic models has been tested. The observed data are not compatible with a two-allele, one-locus model, but they fit a three-allele, one-locus model and a complementation two-locus model if additional familial correlation is allowed.