Association and sibpair analysis for the HLA, Gm, Km, and insulin polymorphisms in multiplex IDDM families

Authors

  • R. Fimmers,

    1. Institut für Medizinische Statistik, Dokumentation und Datenverarbeitung der Universität Bonn, Federal Republic of Germany
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  • M. Neugebauer,

    1. Institut für Medizinische Statistik, Dokumentation und Datenverarbeitung der Universität Bonn, Federal Republic of Germany
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  • J. Dennert,

    1. Institut für Medizinische Statistik, Dokumentation und Datenverarbeitung der Universität Bonn, Federal Republic of Germany
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  • T. Wienker,

    1. Institut für Medizinische Statistik, Dokumentation und Datenverarbeitung der Universität Bonn, Federal Republic of Germany
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  • M. P. Baur

    Corresponding author
    1. Institut für Medizinische Statistik, Dokumentation und Datenverarbeitung der Universität Bonn, Federal Republic of Germany
    • Institut für Medizinische Statistik, Dokumentation und Datenverarbeitung der Universität Bonn, Sigmund-Freud Str. 25, 5300 Bonn, Federal Republic of Germany

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Abstract

A log-linear model was used to analyze three-way interactions between IDDM and pairs of genetic markers. To do this, a special sample dataset was selected by taking one affected and one unaffected child from each family. Some three-way interactions were found for associations between insulin-dependent diabetes mellitus (IDDM), HLA-DR, and DQ restriction enzyme fragment length polymorphism (RFLP) patterns. No three-way interaction was found for IDDM, HLA-DR, and Gm or Km. An extended sibpair analysis was applied to the HLA-B,DR loci and to the Gm, Km, and insulin gene polymorphisms. The well-known result for IDDM and HLA was reproduced. For Gm, Km, and the insulin gene no cosegregation with IDDM could be found.

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