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Keywords:

  • bipolar;
  • unipolar;
  • hierarchical diagnosis;
  • HLA

Abstract

The NIMH family study consisted of 172 probands with affective disorder and 43 normal control probands. Psychiatric disorders were diagnosed in relatives over the age of 18 using Research Diagnostic Criteria based on personal interviews, medical records, and family history information. Some families were also genotyped for red cell, serum, and HLA marker loci. Previous analyses of these data have shown that affective disorders aggregate in families. Segregation analyses have not been able to define the mode of inheritance.