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Keywords:

  • manic depression;
  • major affective disorder;
  • bipolar;
  • unipolar;
  • family analysis;
  • genetic susceptibility;
  • genetic markers

Abstract

The Toronto-Rochester Depression study consisted of 116 pedigrees ascertained for multiple cases of major affective disorders. Among the 857 psychiatrically evaluated family members, of whom more than 85% were given a structured interview, 363 had major affective disorder by Research Diagnostic Criteria and 385 had no history of psychological aberration. HLA region genes were typed in 804 of these persons.