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Keywords:

  • chromosomal linkage markers;
  • birth cohort;
  • sex;
  • chromosome 11;
  • X-chromosome;
  • chromosome 6;
  • HLA;
  • insulin;
  • ras oncogene;
  • color blindness;
  • restriction fragment length polymorphism (RFLP)

Abstract

Recent data on chromosomal linkage markers in affective disorders indicate that single locus inheritance is involved in these disorders. The presence of a single locus has not been detectable using segregation analysis on family study data from large populations, possibly because of both heterogeneity and birth cohort and sex differences in diagnostic frequencies.