Familial analysis of bipolar affective disorder using logistic models

Authors

  • Dr. John Blangero,

    Corresponding author
    1. Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas
    • Department of Genetics, Southwest Foundation for Biomedical Research, West Loop 410 at Military Dr., P.O. Box 28147, San Antonio, TX 78284

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  • Robert C. Elston

    1. Department of Biometry and Genetics, LSU Medical Center, New Orleans, Louisiana
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Abstract

Data on bipolar affective disorder in 187 pedigrees from the Collaborative Depression Study were analyzed using logistic models that have been extended to incorporate age of onset information. Logistic regression analysis and segregation analysis revealed evidence for complex familial effects on this disorder.

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