Linkage analysis with cohort effects: An application to X-linkage


  • Dr. Paul Van Eerdewegh

    Corresponding author
    1. Department of Psychiatry, Washington University and the Jewish Hospital of St. Louis, St. Louis
    • Department of Psychiatry, Jewish Hospital of St. Louis, 216 South Kingshighway, St. Louis, MO 63110

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The LIPED program has been modified to incorporate cohort effects in a linkage analysis. Very significant positive lod scores are obtained between bipolar affective disorder and both the deutan and protan markers on the X-chromosome. Lod score methods are shown to be sensitive to the specification of the age onset distributions and the parameters of the model of transmission.