An oliogenic disease displaying weak marker assocations: A summary of contributions to problem 1 of GAW9


  • Dr. Susan E. Hodge

    Corresponding author
    1. Division of Clinical and Genetic Epidemiology, New York State Psychiatric Institute
    2. Department of Psychiatry, and Division of Biostatistics, Columbia University, New York, New York
    • New York State Psychiatric Institute, Unit 14, 722 West 168th Street, New York, NY 10032

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Problem 1 consisted of artificial data simulated from an oligogenic (four-locus) disease model. The data set contained 200 nuclear families with at least one affected child and 100 control families with no affected members. Two of the disease loci were intended to be detectable via association analysis but not necessarily via linkage analysis, and the other two were virtually undetectable in this data set. Participants used association analysis, linkage analysis, and segregation analysis to analyze these data. Their findings are summarized, and analysis strategies are discussed. ©1995 Wiley-Liss, Inc.