Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease

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Abstract

Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed. ©1995 Wiley-Liss, Inc.

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