Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease



Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed. ©1995 Wiley-Liss, Inc.