Screening a 2 cM genetic map for allelic association: A simulated oligogenic trait


  • Dr. David L. Duffy

    Corresponding author
    1. Queensland Institute of Medical Research, Brisbane, Australia
    • Room 6030D, Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe Street, Baltimore, MD 21205

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In this paper, we explore the use of a variety of familial transmission tests (and case-control analyses) to screen for allelic associations in simulated marker data of a quality (2 cM map) that will feasibly arise from genomic scans within the next 5-10 years. We demonstrate a form of the transmission-disequilibrium test extended to multiallele systems. The methods used were log-linear and related models implemented largely using standard statistical packages. ©1995 Wiley-Liss, Inc.