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Keywords:

  • transmission/disequilibrium test;
  • mod score;
  • linkage analysis

Abstract

We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. © 1995 Wiley-Liss, Inc.