Sib-based detection of QTLs

Authors

  • Dr. Brian K. Suarez,

    Corresponding author
    1. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri
    2. Department of Genetics, Washington University School of Medicine, St. Louis, Missouri
    • Washington University School of Medicine, 4940 Children's Place, St. Louis, MO 63110

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  • Carol L. Hampe,

    1. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri
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  • Dennis O'rourke,

    1. Department of Anthropology, University of Utah, Salt Lake City, Utah
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  • Paul Van Eerdewegh,

    1. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri
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  • Theodore Reich

    1. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri
    2. Department of Genetics, Washington University School of Medicine, St. Louis, Missouri
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Abstract

Association and transmission/nontransmission analyses were used in a split sample design to identify disease susceptibility alleles at two loci. Sib-pair analysis on various subsets of the data identified an additional four regions that yielded signals of disease predisposing quantitative trait loci (QTLs). Three of these four regions represented Type I errors. A new simulation indicates that a multiplex sampling strategy would substantially improve QTL detection for this oligogenic transmission model. © 1995 Wiley-Liss, Inc.

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