Segregation and linkage analysis of the complex trait Q1

Authors

  • Dr. Larry D. Atwood,

    Corresponding author
    1. Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas
    • Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 28147, San Antonio, TX 78228-0147

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  • Braxton D. Mitchell,

    1. Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas
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  • Nicole C. Stowell

    1. Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas
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Abstract

Segregation and linkage analysis of GAW9 Problem 2 quantitative trait 1 (Q1) was performed. Eight segregation models comprising all possible combinations of the environmental factor (EF), quantitative trait 2 (Q2), and quantitative trait 3 (Q3) as covariates were considered. Seven of the eight segregation models showed strong evidence for a major gene, the other model was marginal. When all genotypes are known, some evidence for linkage (lod > 2) was found to all three of the markers that affect Q1. Furthermore, four of the eight models each showed some linkage (lod > 2) to two of the three markers that affect Q1 with no false positives. Each of these segregation analysis major genes is a hybrid combination of the true multiple loci that affect Q1. © 1995 Wiley-Liss, Inc.

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